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Binghe Wang

Regents' Professor; GRA Eminent Scholar
Education

BS, Medicinal Chemistry, Beijing Medical College, 1982
Ph.D. Dept. of Medicinal Chemistry, University of Kansas, 1991
Postdoc: Dept. of Chemistry, University of Arizona, 1992
Postdoc: Dept. of Pharmaceutical Chemistry, University of Kansas,1993

Specializations

Drug design, organic synthesis, drug delivery, computational chemistry, drug screening, instrument analysis, cell culture, biochemistry, enzyme inhibition, fluorescent sensing, click chemistry, etc.

Biography

Work in Dr. Binghe Wang’s lab cover drug design (cancer, infectious diseases, inflammation, etc), drug delivery (delivering gasotransmitters, prodrugs, receptor-mediated drug delivery, click chemistry-mediated drug delivery, etc.), fluorescent sensing and new diagnostics (carbohydrate biomarkers, anions, peroxides, sulfides, etc.), click chemistry (DNA modifications, new click chemistry, click chemistry in drug delivery), boronic acid chemistry, and carbohydrate recognition.

Publications

Recent publications:
1. Zheng, Y.; Ji, X.; Yu, B.; Ji, K.; Gallo, D.; Csizmadia, E. Zhu, M.; De La Cruz, L.K.; Choudhary, M.R.; Chittavong, V.; Pan, Z.; Yuan, Z.; Otterbein, L.; Wang, B. “Enrichment-triggered Prodrug Activation Demonstrated through Mitochondriatargeted Delivery of Doxorubicin and Carbon Monoxide” Nature Chem. 2018, manuscript accepted.
2. Yu, B.; Zheng, Y.; Yuan, Z.; Li, S.; Zhu, H.; De La Cruz, L. K.; Zhang, J.; Ji, K.; Wang, S.; Wang, B. “Toward Direct Protein S-Persulfidation: A Prodrug Approach that Directly Delivers Hydrogen Persulfide” J. Am. Chem. Soc. 2018, 140, 30-33.
3. Ji, X.; Pan, Z.; Zhang, J.; Ji, K.; Chittavong, V.; Wang, B. “Organic CO prodrugs activated by endogenous ROS” Org. Lett. 2018, 20, 8-11.
4. De La Cruz, K; Benoit, S.; Pan, Z.; Yu, B.; Maier, R.; Ji, X.; Wang, B. “Click, release, and fluoresce: a cascade prodrug for co-delivery of carbon monoxide, a drug payload, and a fluorescent reporter” Org. Lett. 2018, 20, 897-900
5. Zheng, Y.; Yu, B.; Li, Z.; Yuan, Z.; Wang, S.; Lefer, D.J.; Wang, B. “Novel Esterase-sensitive Prodrug Approach for Controllable Delivery of Persulfide” Angew Chem. Int. Ed. 2017, 56,11749-53.
6. Ji, X.; Zhou, C.; Ji, K.; Aghoghovbia, R.E.; Pan, Z.; Chittavong, V.; Ke, B.; and Wang, B. “Click and Release: A Chemical Strategy toward Developing Gasotransmitter Prodrugs by Using an Intramolecular Diels-Alder Reaction” Angew. Chem. Int. Ed. Engl. 2016, 55, 15846-15851.