Binghe Wang
Regents ‘Professor, Frank Hannah Professor, Georgia Research Alliance Eminent Scholar, and Georgia Cancer Coalition Distinguished Cancer Scientist, Department of Chemistry- Education
BS, Medicinal Chemistry, Beijing Medical College, 1982
Ph.D. Dept. of Medicinal Chemistry, University of Kansas, 1991
Postdoc: Dept. of Chemistry, University of Arizona, 1992
Postdoc: Dept. of Pharmaceutical Chemistry, University of Kansas,1993
- Specializations
Drug design, organic synthesis, drug delivery, computational chemistry, drug screening, instrument analysis, cell culture, biochemistry, enzyme inhibition, fluorescent sensing, click chemistry, etc.
- Biography
Work in Dr. Binghe Wang’s lab cover drug design (cancer, infectious diseases, inflammation, etc), drug delivery (delivering gasotransmitters, prodrugs, receptor-mediated drug delivery, click chemistry-mediated drug delivery, etc.), fluorescent sensing and new diagnostics (carbohydrate biomarkers, anions, peroxides, sulfides, etc.), click chemistry (DNA modifications, new click chemistry, click chemistry in drug delivery), boronic acid chemistry, and carbohydrate recognition.
- Publications
Recent publications:
- Yang, X.; Lu, W.; Alves de Souza, R.; Mao, Q.; Baram, D.; Tripathi, R.; Wang, G.; Otterbein, L.E.; Wang, B. "Metal-free CO Prodrugs Activated by Molecular Oxygen Protect against Doxorubicin-induced Cardiomyopathy in Mice" Med. Chem. 2024, 67, 18981-18992.
- Bansal, S.; Wang, B. “A Critical Factor in Reactive Oxygen Species (ROS) Studies: The Need to Understand the Chemistry of the Solvent Used: The Case of DMSO” Sci. 2024, 15, 17843-17851
- Liu, D.; Yang, X.; and Wang, B. “A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes that Detect CO and Those that Only Detect Chemically Reactive CO Donors (CORMs), But not CO” 2024, Org. Chem. 89, 17891-17909.
- Lu, W.; Yang, X.; and Wang, B. “Carbon Monoxide Potentiates the Effect of Corticosteroids in Suppressing Inflammatory Responses in Cell Culture.” Med. Chem. 2025, 120, 118092.
- Bauer, N.; Mao, Q.; Vashistha, A.; Du, N.; Otterbein, L.E.; Tan, C.; de Caestecker, M.; and Wang, B. “COmpelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide” Res. Rev. 2025, manuscript accepted.
- Abdelfattah, A.G.; Bansal, S.; Quaye, J.A.; Kongdengadan, S.M.; Gadda, G.; and Wang, B. “Thioether Oxidation Chemistry in Reactive Oxygen Species (ROS)-Sensitive Trigger Design: A Kinetic Analysis” Lett. 2025, 27,3071-3076.
- Liu, D.; Mao, Q.; Yang, X.; Bauer, N.; Challa, S.; and Wang, B. “CO as a Potential Therapeutic Agent: An Initial Investigation of Dosing and Concentration Dynamics in Solution” Chem. Res. 2025, https://doi.org/10.1007/s00044-025-03405-5.