CHEMISTRY NEWS
For the most up-to-date news from the Department of Chemistry.
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Recent News
PUBLICATION: "Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide"
Abstract
Carbon monoxide (CO) is an endogenous signaling molecule. It is produced via heme degradation by heme oxygenase (HMOX), releasing stoichiometric amounts of CO, iron, and biliverdin (then bilirubin). The HMOX-CO axis has long been shown to offer beneficial...read more ❯
Georgia State Student Goes From No College Ambition to Future Scientist
Georgia State chemistry major Marvin Center went from thinking college wasn't in the cards for him to setting his sights on a career in science.read more ❯
PUBLICATION: "Uncovering the Role of Distal Regions in PDK1 Allosteric Activation"
Abstract
Allosteric regulation is a pivotal mechanism governing a wide array of cellular functions. Essential to this process is a flexible biomolecule allowing distant sites to interact through coordinated or sequential conformational shifts....read more ❯
Dr. Kuangcai Chen Co-Authors Chemosensors Best Paper Award Winner
Dr. Kuangcai Chen Co-Authors Chemosensors Best Paper Award Winner
Congratulations to Dr. Kuangcai Chen, adjunct faculty member and former researcher in the Department of Chemistry, whose co-authored paper, “Smartphone-Based Portable Bio-Chemical Sensors: Exploring...read more ❯
PUBLICATION: "MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer"
Abstract
Despite the widespread application of immunotherapy, treating immune-cold tumors remains a significant challenge in cancer therapy. Using multiomic spatial analyses and experimental validation, we identify MGAT1, a glycosyltransferase, as a pivotal factor...read more ❯
PUBLICATION: "Oxidation of α-hydroxy acids by D-2-hydroxyglutarate dehydrogenase enzymes"
Abstract
α-Hydroxy acids are naturally occurring organic molecules with various medical and industrial applications. However, some α-hydroxy acids, like D-2-hydroxyglutarate (D2HG), have been implicated in cancers and neurometabolic disorders such as D2HG...read more ❯
PUBLICATION: "A region of mumps virus nucleoprotein affects defective interfering particle production"
Abstract
Mumps virus (MuV) is a negative-sense, single-stranded RNA virus belonging to the family Paramyxoviridae. MuV causes acute infection of the parotid glands, and the infection can result in severe cases of encephalitis, meningitis and deafness in humans....read more ❯
PUBLICATION: "Identifying and controlling inactive and active conformations of a serine protease"
Abstract
Serine proteases have been proposed to dynamically sample inactive and active conformations, but direct evidence at atomic resolution has remained elusive. Using nuclear magnetic resonance (NMR), we identified a single residue, D164, in exfoliative toxin...read more ❯
PUBLICATION: "Solvent-Dependent Emissions Properties of a Model Aurone Enable Use in Biological Applications"
Abstract
Fluorophores are powerful visualization tools and the development of novel small organic fluorophores are in great demand. Small organic fluorophores have been derived from the aurone skeleton, 2-benzylidenebenzofuran-3(2H)-one. In this study, we have...read more ❯
PUBLICATION: "Cartilage-targeting fluorophores for early detection of arthritis in the NIR-II window"
ABSTRACT
The development of cartilage-targeting fluorophore 28 (CARF28) represents a significant advance in the field of biomedical imaging, particularly for the diagnosis and monitoring of rheumatoid arthritis (RA) and other cartilage-related conditions. By...read more ❯
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