The Department of Chemistry is housed in the Petit Science Center, the Science Annex and the Natural Science Center. Petit Science Center and the Natural Science Center feature teaching labs, offices, service modules, and research laboratories. Major facilities include a state-of-the-art high-field regional NMR core facility with 600 and 400 MHz Bruker NMR spectrometers.
The Department is also home to a combinatorial synthesis facility. Other instrumentation includes UV/vis, infrared, fluorescence and circular dichroism spectrophotometers, stopped flow instrumentation, two Biacore instruments, bead sorter for combinatorial chemistry, ITC and DSC instruments. Compound separation and analysis is achieved via HPLC, FPLC, centrifugal partition chromatography, capillary electrophoresis and GC/mass spectrometry. The departmental NMR Facility is managed by a full time Ph.D. as is the departmental Mass Spectrometry Facility. Instrumentation shared with the Biology Department includes environmental rooms as well as a centralized DNA and peptide synthesis and analysis facilities.
The Chemistry Department has a robust history of leveraging computational methods to conduct research, including:
- PHOTON: This 15-node cluster with 360 cores and 2,880 GB RAM. This system is connected through 56Gbps FDR InfiniBand interconnect. Each node in this system features 800GB NVMe scratch space to support applications that use frequent scratch access.
- ACIDS: An NSF-funded resource with 2,000 compute cores, 16 TB memory, and 32 NVIDIA V100 GPUs. It also has a 250 TB usable data storage capacity and a 200 TB scratch high-performance parallel file system.
- TReNDS: This cluster provides 2,500 compute cores, 30 TB RAM, 40 NVIDIA V100 GPUs, and 8 NVIDIA A100 GPUs. TReNDS is served by storage subsystems totaling 1.5PB storage capacity.
- CDER: This NSF-sponsored resource provides an additional 316 cores, 1664 GB RAM, and 40 TB storage, NVIDIA GeForce GTX 980, NVIDIA GeForce GTX TITAN X, and 4 * NVIDIA V100 16GB GPUs for researchers.
- CDERHD: This 12-node Hadoop/Spark cluster features 200 cores, 640 GB memory, and 112 TB HDFS storage.
Culture and Fermentation
The fermentation facility is shared with the Biology Department and includes "state-of-the-art" computerized New Brunswick 30 liter and 150 liter fermenters, with temperature and pH controls, cell harvesting capacity, and a large scale (up to 1 kg of cells) homogenizer and Dynamill Cell distributor. The centralized facility also boasts a 3 Liter pilot fermenter/chemoststat. In addition the facility includes a novel, recently patented, centrifugal fermentation facility.
DNA Sequencing and Protoemics
A shared core facility with Biology Department .
A wide array of equipment and facilities dedicated to imaging biological samples from the atomic to the macroscopic levels:
- Atomic Force Microscopy
- Confocal and Deconvolution Microscopy
- Microscopy Core Facilities
- Photographic Facilities
The Mass Spectrometry facilities at Georgia State University are research resources to provide modern instrumentations and expertise in the analysis of chemical and biological molecules with state-of-the-art mass spectrometers. The Facilities operates four instruments including a Waters’ LCMS with Xevo-G2-xs Q-TOF (ESI(APCI)-Q-TOF) MS and an Acquity I class-UPLC, Bruker’s UltrafleXtreme MALDI TOF-TOF, an LCMS with Waters Xevo-TQ-s micro [ESI(APCI)-Triple Quadruple] MS and Acquity H class-UPLC and Agilent’s 5973 network MS with 6890N network GC system.
The facilities can perform routine low-resolution analysis by EI, ESI, APCI and MALDI of small organic molecules, biomacromolecules such as peptides, proteins, nucleic acids, lipids, and oligosaccharides, polymers, and metals. They also routinely conduct accurate mass analyses and elemental composition determinations, tandem (MS/MS) experiments and LC separations with MS detection and quantitation as requested by users.
The facilities also provides service on protein identification, protein characterization and intact mass analysis.
Georgia State Univeristy's NMR Research Facility is dedicated to providing campus wide access to sophisticated NMR spectroscopy instrumentation. The facility’s focus is to provide NMR technical expertise and support, and engage in collaborative research and consultation, promoting interdisciplinary discovery and innovative thinking within the campus and the capital community.
Currently, the facility operates Bruker Avance III HD 600MHz, Bruker Avance III 400MHz, and Bruker Avance 400MHz spectrometers. The Bruker Avance III HD 600MHz NMR is equipped with triple resonance probe. It is dedicated to macromolecular research such as proteins, peptides, oligonucleotides, lipids, and carbohydrates. Both the Bruker AVIII 400MHz and AV 400MHz NMR spectrometers are equipped with BBFO probes where the broadband channel can observe frequencies from 109Ag to 19F. The two Bruker 400 MHz spectrometers are used primarily for the analysis of small molecules.
- Multiple UV/vis spectrophotometers
- Nicolet Magna-IR Fourier-Transform 560 Spectrometer
- Hitachi-Perkin Elmer MPF44a and SLM-8000C spectrofluorimeterles
- Photon Technology International QM1 fluorescence spectrophotometer
- JASCO J-810 circular dichroism spectrophotometer
- Hi-Tech SF-51 stopped-flow spectrophotometer
- Fluostar fluorescence/absorbance microplate reader
- Beckman Biosys 2000 FPLC System
- Beckman Avanti J25 centrifuge
- Molecular Dynamics Storm Gel Imaging System
- Molecular Dynamics FluorImager SI
- Advanced ChemTech Model 496 multiple organic synthesizer (for parallel synthesis)
- Surface Plasmon Resonance Biacore 2000 and 3000 instruments
- 2 Microcal VP ITCs and 1 Microcal VP DSC
Department of Chemistry
Georgia State University
161 Jessie Hill Jr. Drive
391 Petit Science Center
Atlanta, GA 30303
(Only for stockroom concerns)
Hours: Monday - Friday
10 a.m. - 12 p.m., 2 - 4 p.m.
Department of Chemistry
Georgia State University
P.O. Box 3965
Atlanta, GA 30302-3965