Dr. Ivaylo Ivanov has been awarded a new 5-year NIH grant entitled “Integrative Modeling of Biomolecular Machinery in Nucleotide Excision Repair” for a total of $2.1M (2022-2027; R01-ES032786) from the National Institute of Environmental Health Sciences. The project will leverage new computational and hybrid modeling approaches to provide unified knowledge of the assembly, dynamics and function of key complexes in nucleotide excision repair – the most versatile pathway for removal of DNA damage resulting from exposure to environmental carcinogens. Unveiling the interplay of molecular-level mechanisms and disease mutations in these complexes will yield understanding of severe genetic disorders associated with cancer, aging, and developmental defects – xeroderma pigmentosum, trichothiodystrophy, Cockayne syndrome and related diseases. Success of the project will thus impact understanding of the roles of environmental and genetic factors in human disease etiology, opening new avenues to devise effective treatments."
Congratulations to Dr. Ivaylo Ivanov on receiving a newly funded $2.1M 5-Year NIH Grant!