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Peng George Wang

Chemistry Chair / Professor / Georgia Research Alliance Eminent Scholar

B.S. (1984): Nankai University, China
Ph.D (1990) : University of California, Berkeley


Peng George Wang obtained his B.S. Degree in Chemistry from Nankai University, China in 1984 and his Ph.D. Degree in organic chemistry from University of California, Berkeley in 1990. He then conducted postdoctoral research in Scripps Research Institute and became an Assistant Professor in 1994 in University of Miami. From 1997 to 2003, he was a faculty at Wayne State University. In 2003, he took a position in the Departments of Biochemistry and Chemistry at Ohio State University as Ohio Eminent Scholar in Macromolecular Structure and Function.  In 2011 He became Professor and Georgia Research Eminent Scholar in Chemical Glycobiology in the Department of Chemistry at Georgia State University.

Research Interests:

Bioorganic Chemistry, Synthesis of Natural Products, Medicinal Chemistry, Carbohydrate Chemistry, Biotechnology, Bioengineering, Green Chemistry, Bioanalytical Chemistry

The main research focus in Wang’s laboratory is in GLYCOSCIENCE: —investigation on carbohydrates in chemical, biological, agricultural and bioengineering sciences (glyco = sugar). Advances in biologicalscience have demonstrated that carbohydrates serve not only as structural components and energy sources, but also as key elements in virtually alllife processes, including bacterial and viral infections, cell adhesion in inflammation and metastasis, differentiation, development, regulation,and many other intercellular communication and signal transduction events. Wang’s laboratory is using a variety of modern research tools to uncover the biological functions of carbohydrates. We are working on four research areas:

  1. Glycochemistry We synthesize uncommon sugar libraries through novelsynthetic methodology and conjugate them to a variety of parent drug molecules to produce novel sugar-drug conjugates for enhanced targeting/transportingactivities. We also design and synthesize organic compounds that can leases reactive nitrogen and oxygen species such as nitricoxide radicals in biological systems.
  2. Glycobiochemistry/Glycobiology This area involves basic biochemical characterization of carbohydrate active enzymes (especially a variety of microbial glycosyl transferases) and investigation on the biologicalfunctions of carbohydrates in human immunity, in microbiology andin human diseases. We are looking for answers to some fundamental questions: what is the structural basis that controls the specificityof a glycosyltransferase? what is the relation between bacterial surface polysaccharides with human natural antibody? how carbohydrates are used in transplantation? how does malfunction in carbohydrate biosynthesis cause human diseases?
  3. Glycotechnology This area includes biosynthetic pathway engineering for the synthesis of glycopharmaceuticals (sugar-containing natural products), polysaccharides for vaccine development, and biomedically important human glycoproteins. We also utilize a variety of enzymes, inorganic synthesis, and develop environmentally benign catalysis.
  4. Glycoanalysis/Glycomics This area includes analysis ofcarbohydrate composition, sequences and structures, and their interaction with proteins through mass spectroscopy (MS), nuclear magnetic resonance(NMR), quartz crystal microbalance (QCM) and other analytical methods. We also construct glycomicroarrays (glycochips) as research tools inglycomics.



Selected Publications:

  1. Han W, Wu B, Li L, Zhao G, Woodward R, Pettit N, Cai L, Thon V, Wang PG. “Defining Function of Lipopolysaccharide O-antigen Ligase WaaL Using Chemoenzymatically Synthesized Substrates”. The Journal of Biological Chemistry2012, 287(8):5357-65.
  2. Li L, Woodward R, Ding Y, Liu XW, Yi W, Bhatt VS, Chen M, Zhang LW, Wang PG. “Overexpression and topology of bacterial oligosaccharyltransferase PglB”. Biochemical Biophysics Research Communications2010, 394(4):1069-74.
  3. Woodward R, Yi W, Li L, Zhao G, Eguchi H, Sridhar PR, Guo H, Song JK, Motari E, Cai L, Kelleher P, Liu X, Han W, Zhang W, Ding Y, Li M, Wang PG. “In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz”. Nature Chemical Biology2010, 6, 418-423.
  4. Zhao, Guohui; Guan, Wanyi; Cai, Li; Wang, Peng George. “Enzymatic route to preparative-scale synthesis of UDP-GlcNAc/GalNAc, their analogues and GDP-fucose” Nature Protocal2010, 5(4): 636-646.
  5. Yi W, Liu X, Li Y, Li J, Xia C, Zhou G, Zhang W, Zhao W, Chen X, Wang PG. “Remodeling Bacterial Polysaccharides by Metabolic Pathway Engineering”. Proceedings of National Academy Sciences2009, 106(11), 4207-4212.
  6. Yi, Wen; Shen, Jie; Li, Jianjun; Wang, Peng George. “A Bacterial Homolog of Human Blood Group A Transferase”. Journal of the American Chemical Society2008. 130(44), 14420-14421.
  7. Lu, Dongning; Nadas, Janos; Zhang, Guisheng; Johnson, Wesley; Zweier, Jay L.; Cardounel, Arturo J.; Villamena, Frederick A.; Wang, Peng George. “4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-Controlled NO-Donors: The Next Generation of S-Nitrosothiols”. Journal of the American Chemical Society2007, 129(17), 5503-5514.
  8. Xia, Chengfeng; Zhang, Wenpeng; Zhang, Yalong; Woodward, Robert L.; Wang, Jinhua; Wang, Peng George. “Facile synthesis of biotin-labeled α-galactosylceramide as antigen for invariant natural killer T cells”. Tetrahedron 2009, 65(32), 6390-6395.
  9. Wang, Peng George. “Sugars synthesized in a snap”. Nature Chemical Biology 2007, 3(6), 309-310.
  10. Guo H, Yi W, Zhang W, Song J, and Wang PG. “Molecular Analysis of O-antigen gene cluster of Escherichia coli O86:B7 and characterization of the chain length determinant gene (wzz)”. Applied Environmental Microbiology2005, 71(12), 7995-8001.
  11. Yi W, Shao J, Zhu L, Li M, Singh M, Lu Y, Lin S, Li H, Ryu K, Shen J,Guo H, Yao Q, Bush CA, and Wang PG. “Escherichia coli O86 O-Antigen Biosynthetic Gene Cluster and Stepwise Enzymatic Synthesis of Human Blood Group B Antigen Tetrasaccharide”.Journal of American Chemistry Society2005, 127, 2040-2041.

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