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Markus Germann

Professor / Biophysical / Safety Director
Education

1982   M.S.    Chemical Engineering Technikum Winterthur, Switzerland
1989   Ph.D.    Nucleic Acids Biochemistry University of Calgary, Canada
1990   Post Doc.   Physical Biochemistry University of Calgary, Canada

Biography

Research Interest:

DNA damage: Effect on DNA structure and repair/recognition by repair enzymes.  Unusual DNA constituents: To study and control DNA stability, recognition and dynamics. 
HIV- RNA binding Zinc fingers: Design, structure and combinatorial methods to generate small RREIIB RNA binding zinc fingers that inhibit rev binding and virus production. 
NMR imaging and Metabonomics

Publications

Representative Publications:

  1. MD and NMR Analysis of Choline and TMA Binding to Duplex DNA: On the Origins of Aberrant Sequence-Dependent Stability by Alkyl Cations in Aqueous and Water-Free Solvents. Portella, G., Germann, M.W., Hud, N. V. & Orozco, M.: Journal of the American Chemical Society, (2014) 136, 3075-3086.
  2. Molecular basis for sequence-dependent induced DNA bending. Rettig, M., Germann, M.W., Wang, S.  & Wilson, W. D.: ChemBioChem (2013), 14, 323-331.
  3. Insight into the modulation of Shaw2 Kv channels by general anesthetics: Structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR. Zhang, J., Qu, X., Covarrubias, M. & Germann, M.W.: BBA – Biomembranes (2013), 1828, 595-601.
  4. Supercooled Aqueous NMR Using Agarose Gels. Spring, A.M., Germann, M.W.: Analytical Biochemistry. (2012), 427, 79-81.
  5. Structural Basis of the RNase H1 Activity on Stereo Regular Borano Phosphonate DNA/RNA Hybrids. Johnson, C.N., Spring, A.M., Shaw, B.R  & Germann, M.W.: Biochemistry (2011), 50, 3903-3912,
  6. An economy of chemicals: sea hare use sun-screening mycosporine-like amino acids as intraspecific alarm cues. Kicklighter, C.E., Kamio, M., Nguyen, L., Germann, M.W. & Derby, C.E.: PNAS (2011), 108, 11494-11499.

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