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Jerry C. Smith

Assoc. Professor / Biophysical

B.S. (1965): University of Mississippi
Ph.D. (1971) : University of North Carolina, Chapel Hill
Postdoc (1972) : Arizona State University
NIH Postdoctoral Fellowship & Re (1974) : University of Pennsylvania


Biophysical Chemistry


Research Interest:

My research interests concern the elucidation of the molecular basis for the potent transdermal penetration enhancement (TPE) properties of a series of imilnosulfurane and related compounds, the activity of which exceed that of Azone, a common reference TPE that is in clinical use. These investigations utilize various biophysical techniques including both scanning and titration calorimetry, 31P and 1H NMR, static and dynamic depolarization studies and the use of computational techniques to ascertain the location(s) of these compounds in the various skin models that include phospholipid bilayaers, these bilayers supplemented with cholesterol, and related preparations based on ceremides .

I also serve as a Director of the long-running NSF-funded chemical education program entitled “chemistry Collaborations, Workshops and Communities of Scholars”. This Program meets its mandate from NSF to improve chemical education, primarily at the undergraduate level, by running both short (2-3 days) and intensive five- and six-day workshops plus symposia, and mini workshops at the BCCE. The workshops cover both pedagogical and topical aspects of chemistry. The Program has served the needs of over 1,200 participants, primarily faculty and staff from two-year institutions to research universities, and has affected the learning of an estimated 1,000,000 students.


Representative Publications

  1. Smith, J.C., Chandrasekaran, S. & Strekowski, L.S. (1999). Interaction of the Probe Oxonol V and the Drug Candidate LS8 with Small Unilamellar DMPC Vesicles. Biophysical Journal, 76, A440.
  2. Smith, J.C., & Chandrasekaran, S. (1998). The Locations of Potential-Sensitive Molecular Probes in DMPC Vesicles: An NMR Investigation. Biophysical Journal 74, A299.
  3. Smith J.C., & Chandrasekaran S. (1997). Location Models for the Probe Oxonol V in 1,2-Dimyristoyl-sn-glycerol-3-phosphocholine(DMPC) Vesicles by NMR Spectroscopy. Biophysical Journal 72, WP443-WP443.
  4. “The Effect of a Potential-Sensitive Barbituric-acid Molecular Probe on the Thermal Phase-Transition Properties of Multilamellar 1,2-Dimyristoyl-sn-glycero-3-phosphocholine Suspensions”, Hamilton, D.; Gill, D. J.; Hopkins, H. P.; Nolan, W. G.; Smith, J. C. Chem. and Phys. Of Lipids, 1995, 75, 109-118
  5. “The Behavior of a Fast-Responding Barbituric Acid Potential-Sensitive Molecular Probe in Bovine Heart Submitrochondrial Particles”, Tran, T. V.; Allen, S.; Smith, J.C. Biochim. Biophys. Acta, 1991, 1059, 265-274.
  6. “NMR, Calorimetric, Spin-Label, and Optical Studies on a Trifluoromethyl-Substituted Syryl Molecular Probe in Dimysteroylphosphatidylcholine Vesicles and Multilamellar Suspensions: a Model for Location of Optical Probes”, Bammel, B. P.; Hamilton, D. D.; Haughland, R. P.; Hopkins, H. P.; Schuette, J.; Szalecki, W.; Smith, J.C. Biochim. Biophys. Acta, 1990, 1024 61-81.
  7. “The Effect of Extrinsic Potential-Sensitive Molecular Probes on the Thermal Phase Transition Properties of Dimysteroylphosphatidylcholine Model Membrane Preparations”, Bammel, B.P.; Fumero, J.; Hopkins, H.P.; Smith, J. C. Biochim. Biophys. Acta, 1988 944, 164-176.