PDB FILES OF EIGHT NUCLEIC ACID BINDING PROTEINS


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Lambda repressor/operator complex
(1lmb.pdb)


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Source: bacteriophage (lambda)
Authors: L. J. Beamer, C. O. Pabo
Reference: "Refined 1.8 Å crystal structure of the lambda repressor-operator complex", J. Mol. Biol. 1992, 227, 177.


DNA polymerase beta (pol beta) (E.C.2.7.7.7) (apo, 31kD domain)
(1bpb.pdb)


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Source: rat (Rattus norvegicus) recombinant form expressed in Escherichia coli
Authors: M. R. Sawaya, H. Pelletier, A. Kumar, S. H. Wilson, J. Kraut
Reference: "Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism.", Science 1994, 264, 1930.


Topoisomerase residues 410-1202
(1bgw.pdb)


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Source: yeast (Saccharomyces cerevisia), expression system: Saccharomyces cerevisiae
Authors: J. M. Berger, S. J. Gamblin, S. C. Harrison, J. C. Wang
Reference: "Structure and mechanism of DNA topoisomerase II", Nature 1996, 379, 225.


Zif268 zinc finger-DNA complex
(1aay.pdb)


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Source: mouse (Mus musculus); expression system: Escherichia coli; strain: BL21 (DE3); expression system plasmid: PZIF89
Authors: M. Elrod-Erickson, M. A. Rould, L. Nekludova, C. O. Pabo
Reference: "Zif268 protein-DNA complex refined at 1.6 Å: a model system for understanding zinc finger-DNA interactions", Structure 1996, 4, 1171.


Human TBP core domain complexed with DNA
(1cdw.pdb)


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Source: human (Homo sapiens); expression system: Escherichia coli;
Authors: D. B. Nikolov, H. Chen, E. D. Halay, A. Hoffman, R. G. Roeder, S. K. Burley
Reference: "Crystal structure of a human TATA box-binding protein/TATA element complex ", Proc. Nat. Acad. Sci. USA 1996, 93, 4862.


HIV-1 reverse transcriptase
(1rev.pdb)


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Source: human immunodeficiency virus type 1; strain: hxb2 isolate; expression system: Escherichia coli; gene: HIV-1 pol
Authors: J. Ren, R. Esnouf, A. Hopkins, C. Ross, Y. Jones, D. Stammers, D. Stuart
Reference: "The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design", Structure 1995, 3, 915.


Ribonuclease A (E.C.3.1.27.5) complexed with (5'-d(ApTpApAp)-3')
(1rcn.pdb)


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Source: ribonuclease A: bovine (Bos taurus) pancreas; DNA: synthetic
Authors: J. C. Fontecilla-Camps, R. de Llorens, M. H. le Du, C. M. Cuchillo
Reference: "Crystal structure of the ribonuclease A,d(ApTpApApG) complex. Direct evidence for extended substrate recognition", J. Biol. Chem. 1994, 269, 21526.


EcoRV endonuclease (E.C.3.1.21.4) complexed with substrate DNA
(1rva.pdb)


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Source: Escherichia coli recombinant form expressed in Escherichia coli
Authors: F. K. Winkler, D. W. Banner, C. Oefner, D. Tsernoglou, R. S. Brown, S. P. Heathman, R. K. Bryan, P. D. Martin, K. Petratos, K. S. Wilson
Reference: "The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments", EMBO J. 1993, 12, 1781.


Citations for the Protein Data Bank

The PDB files on this page were obtained from the Protein Data Bank, and were created by the authors listed above. The Protein Data Bank, maintained by the Research Collaboratory for Structural Bioinformatics is an archival database of the three-dimensional structures of biological macromolecules such as proteins, nucleic acids and carbohydrates.   The stuctures are derived from experimental work such as X-ray diffraction studies and NMR investigations.

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