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Research projects ongoing in the Zheng lab.
Recent publications from this lab.
Current group members.
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Regular seminars and meetings.
Courses taught by Dr.Zheng.
News and positions in the Zheng lab.
Some useful scientific links.

Publications

    J. Wang, C. Luo, Y. G. Zheng. “ A new set of Small molecule inhibitors of PRMTs.” Manuscript in preparation.

    S. Sinha, M. Henary, Y. G. Zheng. “ Near-IR molecules for PRMT inhibition.” Manuscript in preparation.

    C. Guardiani, Y. Feng, X. Xu;Y. G. Zheng, I. Ivanov. “ Interplay between acetylation and methylation in histone H4 tail: A structural perspective.” Submitted.

    M. Ghizzoni, J. Wu, T. Gao, H. J. Haisma, F. J. Dekker, Y. G. Zheng “ 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site.” European Journal of Medicinal Chemistry, 2011, In press. [PDF]

    H. Yuan, D. Rossetto, H. Mellert, W. Dang, M. Srinivasan, J. Johnson, S. Hodawadekar, E. C. Ding, K. Speicher, N. Abshiru, R. Perry, J. Wu, C. Yang, Y. G. Zheng, D. W. Speicher, P. Thibault, A. Verreault, F. B. Johnson, S. L. Berger, R. Sternglanz, S. B. McMahon, J. Cote, R. Marmorstein, “ MYST Protein Acetyltransferase Activity Requires Active Site Lysine Autoacetylation. ” The EMBO Journal, 2011, In press. [PDF]

    Y. Feng, N. Xie, M. Jin, M. R. Stahley, J. T. Stivers, Y. G. Zheng. “ A transient kinetic analysis of PRMT1 catalysis.” Biochemistry, 2011, 50, 7033-7044. [PDF]

    J. Wu, N. Xie, Y. Feng, Y. G. Zheng. “ Scintillation Proximity Assay of Arginine Methylation.” Journal of Biomolecular Screening, 2011, In press. [PDF]

    Y. Feng, J. Wang, S. Asher, L. Hoang, C. Guardiani, I. Ivanov, Y. G. Zheng. “ Histone H4 Acetylation Differentially Modulates Arginine Methylation by an In Cis Mechanism.” The Journal of Biological Chemistry, 2011, 286, 20323-20334. [PDF]

    J. Wu, J. Wang, M. Li, B. Wang, Y. G. Zheng. “ Small molecule inhibitors of HAT Tip60.” Bioorganic Chemistry, 2011, 39, 53-58. [PDF]

    J. Wu, Y. G. Zheng. “ Synthesis of H4 pantetheine adducts for histone acetyltransferase inhibition.” Heterocyclic Communications, 2010, 16, 231-234. [PDF]

    Y. Feng, M. Li, B. Wang, Y. G. Zheng. “Discovery and Mechanistic Study of a Class of Protein Arginine Methylation Inhibitors.” Journal of Medicinal Chemistry, 2010, 53, 6028-6039. [PDF]

    K. Li, C. Luo, D. Wang, H. Jiang, Y. G. Zheng. “Chemical and Biochemical Approaches in the Study of Histone Methylation and Demethylation.” Medicinal Research Reviews , 2010. In press. [PDF]

    J. Ding, Y. Feng, Y. Zhang, Y. G. Zheng. “Protein methylation prediction using granular decision methods.” Intl. J. Soft Computing Bioinformatics, 2010, 1, 19-27. [PDF]

    Y. Feng, N. Xie, J. Wu, C. Yang, Y. G. Zheng. “Inhibitory study of PRMT1 using a fluorescent approach.” Biochemical and Biophysical Research Communications, 2009, 379, 567-572. [PDF]

    J. Wu, N. Xie, Z. Wu, Y. Zhang, Y. G. Zheng. “Bisubstrate inhibitors of Esa1/Tip60.” Bioorganic and Medicinal Chemistry, 2009, 17, 1381-1386. [PDF]

    N. Xie, E. N. Elangwe, S. Asher, Y. G. Zheng. “A dual-mode fluorescence strategy for screening HAT modulators.”Bioconjugate Chemistry, 2009, 20, 360-366. [PDF]

    J. Wu, Y. G. Zheng. “Fluorescent Reporters of the Histone Acetyltransferases.”Analytical Biochemistry, 2008, 380, 106-110. [PDF]

    J. Wu, Z. Chen, M. Goodman, Y. G. Zheng. “Chemical regulation of epigenetic modifications and opportunities of new cancer therapy.”Medicinal Research Reviews, 2008, 28, 645-687. [PDF]

    Z. Chen, Y. G. Zheng. “Synthesis of a coumarin-histone conjugate for HAT fluorescent assay.”Heterocyclic Communications, 2007, 13, 343-346. [PDF]

    Y. Zheng, K. Balasubramanyam, M. Cebrat, D. Buck, A. Zelent, R. M. Alani, P. A. Cole. “Synthesis and Evaluation of a Potent and Selective Cell Permeable p300 Histone Acetyltransferase Inhibitor.”Journal of the American Chemical Society, 2005, 127, 17182-17183. [PDF]

    Y. Zheng, F. Mamdani, D. Toptygin, L. Brand, J. T. Stivers, P. A. Cole. “Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase.”Biochemistry, 2005, 44, 10501-10509. [PDF]

    Y. Zheng, P. R. Thompson, M. Cebrat, L. Wang, M. K. Devlin, R. M. Alani, P. A. Cole. “Selective HAT Inhibitors as Mechanistic Tools for Protein Acetylation.”Methods in Enzymology, 2004, 376 (B), 188-199. [PDF]

    Y. Zheng, J. Orbulescu, X. Ji, F. M. Andreopoulos, S. M. Pham, R. M. Leblanc. “Development of Fluorescent Film Sensors for the Detection of Divalent Copper.”Journal of the American Chemical Society, 2003, 125, 2680-2686. [PDF]

    Y. Zheng, X. Cao, V. K., F.M. Andreopoulos, S. M. Pham, R. M. Leblanc. “Peptidyl Fluorescent Chemosensors for the Detection of Divalent Copper.”Analytical Chemistry, 2003, 75, 1706-1712. [PDF]

    Y. Zheng, K. M. Gattás-Asfura, C. Li, F.M. Andreopoulos, S. M. Pham, R. M. Leblanc. “Design of a Membrane Fluorescent Sensor Based on Photocrosslinked PEG Hydrogel.”Journal of Physical Chemistry B, 2003, 107, 483-488. [PDF]

    Y. Zheng, K. M. Gattás-Asfura, V. Konka, R. M. Leblanc. “A Dansylated Peptide for the Selective Detection of Copper Ions.”Chemical Communications, 2002, 2350-2351. [PDF]

    Y. Zheng, M. Micic, S. V. Mello, M. Mabrouki, F.M. Andreopoulos, V. Konka, S. M. Pham, R. M. Leblanc. “Formation of PEG-Based Hydrogel Via the Photodimerization of Anthracene Groups.”Macromolecules, 2002, 35, 5228-5234. [PDF]

    Y. Zheng, Q. Huo, P. Kele, F.M. Andreopoulos, S. M. Pham, R. M. Leblanc. “A New Fluorescent Chemosensor for Cu2+ Ions Based on the Tripeptide Glycyl-Histidyl-Lysine.”Organic Letters, 2001, 3, 3277-3280. [PDF]

    Y. Zheng, F.M. Andreopoulos, M. Micic, Q. Huo, S. M. Pham, R. M. Leblanc. “A Novel Photoscissile PEG-based Hydrogel.”Advanced Functional Materials, 2001, 11, 37-40. [PDF]

    K. M. Gattás-Asfura, Y. Zheng, X. Cao, V. Konka, F.M. Andreopoulos, S. M. Pham, R. M. Leblanc. “Immobilization of Quantum Dots With Photo-Cross-Linked PEG Hydrogel.”Journal of Physical Chemistry B, 2003, 107, 10464-10469. [PDF]

    M. Micic, Y. Zheng, V. Moy, X. Zhang, F.M. Andreopoulos, R. M. Leblanc. “Comparative Studies of Surface Topography and Mechanical Properties of a Novel Photoswitchable PEG-NC Based Hydrogel.”Colloid and Surface: B Biointerface, 2003, 27, 147-158. [PDF]

    M. Micic, J. Orbulescu, K. Radotic, M. Jeremic, G. Sui, Y. Zheng, R. M. Leblanc. “ZL-DHP Lignin Model Compound at the Air-Water Interface.” Biophysical Chemistry, 2002, 99, 55-62. [PDF]

    Q. Huo, G. Sui, Y. Zheng, P. Kele, T. Hasegawa, J. Nishijo, J. Umemura, R. M. Leblanc. “Metal Complexation with Langmuir Monolayer of Mixed Peptide Lipids.” Chemistry: A European Journal, 2001, 7, 4796-4804. [PDF]
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