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Laura Kibler-Herzog Senior Lecturer, Biochemistry Ph.D., Georgia State University (1992) Dr. Laura Kibler-Herzog Department of Chemistry Georgia State University P.O. Box 4098 Atlanta, Georgia 30302-4098
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My research efforts have focused mainly on the biophysical aspects of certain short chain nucleic acids that have the potential to act as anticancer agents or carriers of small molecules with anticancer activity. These types of compounds show promise as anticancer drugs because they can exert highly selective effects on target cells without toxic side effects. I have investigated both DNA- and RNA-based compounds, including phosphorothioate, methylphosphonate, and phosphodiester double and triple helical complexes.
Representative Publications
Kibler-Herzog, L., Zon, G., Whittier, G., Mizan, S., and Wilson, W.D. (1993). Stabilities of duplexes and triplexes of dA19 + dT19 with alternating methylphosphonate and phosphodiester linkages. Anti-Cancer Drug Design, 8, 65.
Kibler-Herzog, L., Zon, G., Uzanski, B., Whittier, G. and Wilson, W.D. (1991). Duplex stabilities of phosphorothioate, methylphosphonate, and RNA analogs of two DNA 14-mers. Nucleic Acids Research, 19, 2979.
Kibler-Herzog, L., Kell, B., Zon, G., Shinozuka, K., Mizan, S. and Wilson, W.D. (1990). Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes. Nucleic Acids Research, 18, 3545.