Curriculum Vitae
Wei Wang
Contact Information
Home address: 10212 Jarash Pl, NE, Albuquerque, NM 87122, USA
Work address: Department of Chemistry & Chemical Biology, MSC03 2060, University of New Mexico, Clark Hall B56, Albuquerque, NM 87131-0001, USA
Telephone:
505-277-0756
Fax: 505-277-2609
Email: wwang@unm.edu
Research Group Internet Homepage: http://www.unm.edu/~wwang/
Education
Ph.D., Organic Chemistry, February 2000
Dissertation Title: Design, synthesis and evaluation of coumarin-based prodrugs and fluorescence sensors
Advisor: Binghe Wang
Department of Chemistry, North Carolina State University, Raleigh, NC, USA
M.S., Organic Chemistry, June 1993
Thesis Title: Synthesis and
QSAR studies of
Advisors: Kunjian Gu and Ruyun Ji
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
B.S., Chemistry, July 1988
Nanjing Normal University, Nanjing, China
Awards and Honors
Tetrahedron Letters Most Cited Paper 2004-2007 Award
Board Member, Letters in Organic Chemistry
Nominated for the 2006-2007 Outstanding Teacher of the Year Award, University of New Mexico.
The Bruce W. Erickson Young Investigator Award, the American Peptide Society (APS) and the APS Travel Grant Award, the 17th American peptide Symposium/2nd International Peptide Symposium, June 9-15, 2001, San Diego, CA, USA
The Outstanding Research Award, the First Annual North Carolina State University International Research Exposition, North Carolina State University, April 16, 1999, USA
Glaxo Graduate Fellowship, Department of Chemistry, North Carolina State University, 1998-1999, USA
Honors Student and the University Scholarship, Nanjing Normal University, 1984-1987, China
Professional Experience
Department of Chemistry and
Chemical Biology, University of New Mexico
Assistant Professor, August 2003 to present
College of Pharmacy, University of New Mexico, Albuquerque, NM
Adjunct Assistant Professor, June 2005 to present
Principal Investigator, December 2001 to August 2003
Genomics Institute of the Novartis Research Foundation, San Diego, CA
Postdoctoral Fellow (with Professor Victor J. Hruby), February 2000 to December 2001
Department of Chemistry, University of Arizona, Tucson, AZ
Teaching and Research Assistant, August 1996 to February 2000
Department of Chemistry, North Carolina State University, Raleigh, NC
Research Associate, October 1994 to July 1996
Department of Medicinal and Pharmaceutical Chemistry, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Research Associate, July 1993 to September 1994
Shanghai Combined Chemistry Institute, East China University of Science & Technology, Shanghai, China.
Research Assistant, September 1990 to June 1993
Shanghai Institute of Material Medica, Chinese Academy of Sciences, China.
High School Chemistry Teacher, August 1988 to August 1990
Sizhao High School, Dongtai City, Jiangsu Province, China
American Peptide Society
Phi Lambda Upsilon National Honorary Chemical Society and Vice President of Beta Lambda Chapter, 1999-2000
New York Academy of Sciences
Sigma Xi
Arkivoc
Angewandte Chemie International Edition
Asian Journal of Chemistry
Advanced Synthesis & Catalysis
Bioorganic & Medicinal Chemistry
Bioorganic & Medicinal Chemistry Letters
Catalysis Communications
Chemical Biology & Drug Design
Chemical Communications
Chirality
Current Organic Chemistry
European Journal of Chemistry
European Journal of Organic Chemistry
Journal of the American Chemical Society
Journal of Combinatorial Chemistry
Journal of Organic Chemistry
Medicinal Research Reviews
Optical Sensors (Book)
Organic & Biological Chemistry
Organic Letters
Synlett
Tetrahedron
Tetrahedron Letters
The National Science Foundation (NSF)
The American Chemical Society – Petroleum Research Foundation
Funding
1) Project Title: “Development of Novel Sensitive and Selective Fluorescence Spin Probes Used for Detection of ROS in Brain”
Role: PI
Funding Agency: NIH-COBRE
Period: 7/1/2005-6/30/2010
3) Project Title: ““Green” Organocatalysts for Asymmetric Michael Addition Reactions”
Role: PI
Funding Agency: The University of New Mexico, the Research Allocation Committee Small Grant-in-Aid for Research
Period: 10/1/2004-9/30/2005
4) Project Title: “Fluorescence Spin Probes for Detection of ROS Associated Brain Injuries”
Role: PI
Funding Agency: The University of New Mexico, the Research Allocation Committee Large Grant-in-Aid for Research
Period: 1/12/2005-9/30/2005
5) Project Title: “ICAM-1 Mimics as LFA-1 Inhibitors”
Role: PI
Funding Agency: NIH INBRE
Period: 07/01/2005-04/30/2009
6) Project Title: “New Mexico Molecular Library Screening Network”
Role: Co-investigator (PI: Larry A. Sklar)
Funding Agency: The National Institutes of Health (NIH)
Period: 7/1/2005-6/30/2008
7) Project Title: “Development of Competitive LFA-1 Antagonists for Regulating Integrin Functions” Role: PI
Funding Agency: The University of New Mexico Cross-Campus Collaboration in Life Sciences, Period: 1/1/2006-12/31/2006
8) Project Title: “Recyclable and Reusable
Role: PI
Funding Agency: The University of New Mexico, the Research Allocation Committee Large Grant-in-Aid for Research
Period: 1/1/2006-9/30/2006
9) Project Title: “Recyclable and Reusable
Role: PI
Funding Agency: The American Chemical Society – Petroleum Research Foundation (ACS-PRF) Period: 09/01/2006-08/31/2008
10) Project Title: “Quantum Dots for Melanoma Tumor Imaging”
Role: PI
Funding Agency: The Sandia National
Laboratories-University Research Program
Period: 10/01/2006-09/30/2008
11) Project Title: “Quantum Dots for Specific Melanoma Tumor Imaging”
Role: PI
Funding Agency: The University of New Mexico, the Research Allocation Committee Large Grant-in-Aid for Research
Period: 01/01/2007-09/30/2007
12) Project Title: “Bifunctional Molecule Mediated Catalysis”
Role: PI
Funding Agency: The National Science Foundation (NSF)
Period: 05/01/2007-04/30/2010
13) Dean’s Dissertation Fellowship, Graduate Student Jian Wang, University of New Mexico, 2006-2007
14) OGS Pepsi Award, Graduate Student Jian Wang, University of New Mexico, 2006
15) The Dow Research Award, Graduate Student Hao Li, University of New Mexico, May 2007
Publications:
UNM (independent research work, 8/2003-present, 43 papers):
1) Jiang, W.; Fu, Q.-Q.; Fan, H.-Y.; Ho, J.; Wang, W.* “A Highly Selective Fluorescent Probe for Facile Detection of Thiophenols” Angew. Chem. Int. Ed., 2007, 46, 8445-8448.
2) Wang, W.* “Hydrogen-bond Mediated Asymmetric Catalysis” Asian J. Chem., 2007, invited review, submitted.
3) Jiang, W.; Fu, Q.-Q.; Fan, H.Y.; Wang, W.* “An NBD Fluorophore-based Sensitive and Selective Fluorescent Probes for Zinc Ion” Chem. Commun., 2007, in press.
4) Zhang, S.; Chen, X.; Zhang, J.; Wang, W.;* Duan, W.* “An Enantioselective Formal Synthesis of (R)-(+)-a-Lipoic Acid by L-Proline-catalyzed Aldol Reaction” Synthesis, 2007, in press.
5) Wang, W.* “Recent Developments on Organocatalytic Cascade Reactions” Org. Biomol. Chem., 2007, invited review, submitted.
6) Xiong, Q.-J.; Gao, Z.-B.; Wang, W.; Li, M.* “Activation of Voltage-activated Potassium Channels by Chemical Ligands” Trends Pharmacol. Sci., 2007, invited review, in press.
7) Zu, L.-S.; Xie, H.-X.; Li, H.; Wang, J.; Wang, W.* “Three Step Synthesis of Chrial Baclofen via a Highly Enantioselective Organocatalytic Conjugate Addition of Nitromethane to a, b-Unsaturated Aldehydes” Adv. Synth. Catal., 2007, in press.
8) Wang, J.; Li, H.; Xie, H.-X.; Zu, L.-S.; Shen, X.; Wang, W.* “Organocatalytic Enantioselective Cascade Michael-Aldol-Dehydration Reactions: Efficient Assembly of Densely Functionalized Chiral Cyclopentenes” Angew. Chem. Int. Ed., 2007, 46, 9050-9053. This article has been selected as “Hot paper”.
9) Xie, H.-X.; Zu, L.-S.; Li, H.; Wang, J.; Wang, W.* “Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions. Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes” J. Am. Chem. Soc., 2007, 129, 10886-10894. This work has been highlighted in Synfacts.
10) Zu, L.-S.; Xie, H.-X.; Li, H.; Wang, J.; Jiang, W.; Wang, W.* “A Chiral Amine Thiourea Promoted Enantioselective Domino Michael-Aldol Reactions between 2-Mercapto-benzaldehydes and Maleimides” Adv. Synth. Catal., 2007, 349, 1882-1886.
11) Zu, L.-S.; Wang, J.; Li, H.; Xie, H.-X.; Jiang, W.; Wang, W.* “Cascade Michael-aldol Reactions Promoted by Hydrogen-Bonding Mediated Catalysis” J. Am. Chem. Soc., 2007, 129, 1036-1037.
12) Wang, W.* Book Review: “Analogue-Based Drug Discovery” Drug Dev. Ind. Pharm., 2007, 33, 803.
13) Zu, L.-S.; Li, H.; Xie, H.-X.; Wang, J.; Jiang, W.; Tang, T.; Wang, W.* “Synthesis of Highly Functionalized Chiral Cyclopentanes by Catalytic Enantio- and Diastereoselective Double Michael Addition Reactions” Angew Chem. Int. Ed., 2007, 46, 3732-3734. This work has been highlighted in Synfacts.
14) Li, H.; Zu, L.-S.; Xie, H.-X.; Wang, J.; Jiang, W.; Wang, W.* “Enantioselective Organocatalytic Double Michael Addition Reactions” Org. Lett., 2007, 9, 1833-1835. This work has been highlighted in Synfacts.
15) Wang, J.; Heikkinen, L. D.; Li, H.; Zu, L.-S.; Jiang, W.; Wang, W.* “Quinine-Catalyzed Enantioselective Michael Addition of Diphenyl Phosphite to Nitroolefins: Synthesis of Chiral Precursors of a-Substituted b-Amino Phosphonates” Adv. Synth. Catal., 2007, 349, 1052-1056.
This work has been recognized as the most accessed articles in 05/2007 of Adv. Synth. Catal. and highlighted in Synfacts.
16) Li, H.; Wang, J.; Xie, H.-X.; Zu, L.-S.; Jiang, W.; Duesler, E. N.; Wang, W.* “Enantioselective Organocatalytic Cascade Reactions: Facile Synthesis of Chiral 1,2-Dihydroquinolines” Org. Lett., 2007, 9, 965-968.
17) Li, H.; Wang, J.; E-Nunu, T.; Zu, L.-S.; Jiang, W.; Wei, S.-H.; Wang, W.* “One-Pot Approach to Chiral Chromenes via Enantioselective Organocatalytic Domino Oxa-Michael-Aldol Reaction” Chem. Commun., 2007, 507-509.
18) Wang, J.; Zu, L.-S.; Li, H.; Xie, H.-X.; Jiang, W. Wang, W.* “Enantioselective Michael Addition of N-Heterocycles to Enones Catalyzed by a Bifunctional Cinchona Alkaloid Thiourea” invited to contribute to Special Topics Thiourea in Synthesis, 2007, 2576-2580.
19) Wang, J.; Li, H.; Zu, L.-S.; Jiang, W.; Xie, H.-X.; Duan, W.-H.; Wang, W.* “Enantioselective Organocatalytic Conjugate Additions to Enones” J. Am. Chem. Soc., 2006, 128, 12652-12653. This work has been recognized as “Hot Paper” in May 2007 of J. Am. Chem. Soc..
20) Zu,
L.-S.; Wang, J.; Li, H.; Yu, X-H.; Wang, W.* “A Recyclable Fluorous
21) Liu,
S.-Y.; Fan, Y.-P.; Peng, X.-X.; Wang, W.;* Hua, W.-Y.; Akber,
H.; Liao, L.-X.* “A Concise and Enantioselective Approach to the
Total Synthesis of
22) Wang, W.;* Li, H.; Wang, J.; Zu, L.-S.; “Enantioselective Organocatalytic Tandem Michael-Aldol Reactions: One-Pot Synthesis of Chiral Thiochromenes” J. Am. Chem. Soc., 2006, 128, 10354-10355. This work has been recognized as “Hot Paper” in May 2007 of J. Am. Chem. Soc. and highlighted in Synfacts.
23) Wang, J.; Li, H.; Zu, L.; Jiang, W.; Wang, W.* “Organocatalytic, Enantioselective Conjugate Addition of Nitroalkanes to Nitroolefins” Adv. Synth. Catal., 2006, 348, 2047-2050. This work has been recognized as the Most Accessed Articles from 6/2006 to 5/2007 of Adv. Synth. Catal. and highlighted in Synfacts.
24) Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Enantioselective Organocatalytic Michael Addition Reactions between N-Heterocycles and Nitroolefins” Org. Lett., 2006, 8, 1391-1394. This work has been highlighted in Synfacts.
25) Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Highly Enantioselective Organocatalytic Michael Addition Reactions of Ketones with Chalcones” Adv. Synth. Catal., 2006, 348, 425-428. This work has been recognized as the Most Accessed Articles in the year of 2006 on Adv. Synth. Catal..
26)
Zu, L.-S.; Wang, J.; Li, H.; Yu, X-H.; Wang, W.* “Highly
Enantioselective Aldehyde-Nitroolefin Michael Addition Reactions Catalyzed by
Recyclable Fluorous
27) Zhang, S.-L.; Duan, W.-H.;* Wang, W.* “Efficient, Enantioselective Organocatalytic Synthesis of Trichostatin A” Adv. Synth. Catal., 2006, 348, 1228-1234.
28) Li, H.; Wang, J.; Zu, L.-S.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to b-Nitrostyrenes” Tetrahedron Lett., 2006, 47, 2585-2589.
29) Li, H.; Zu, L.-S.; Wang, J.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to Enones” Tetrahedron Lett., 2006, 47, 3145-3148.
30) Mei, Y.; Bentley, P. A.; Wang, W. “A Selective and Sensitive Chemosensor for Cu2+ Based on 8-Hydroxyquinoline” Tetrahedron Lett., 2006, 47, 2447-2449.
31) Wang, J.; Li, H.; Lou, B.; Zu, L.-S.; Guo, H.; Wang, W.* “Enantio- and Diastereoselective Michael Addition Reactions of Unmodified Aldehydes and Ketones with Nitroolefins Catalyzed by a Pyrrolidine Sulfonamid” Eur. Chem. J., 2006, 12, 4321-4332.
32) Wang, J.; Li, H.; Yu, X.-H.; Zu, L-S.; Wang, W.* “Chiral Binaphthyl-Derived Amine-Thiourea Organocatalyst Promoted Asymmetric Morita-Baylis-Hillman Reaction” Org. Lett., 2005, 7, 4293-4296. This work has been recognized as Org. Lett. Hot Paper and the most cited papers published on Org. Lett. in 2005.
33) Wang, J.; Li, H.; Duan, W.-H.; Zu, L-S.; Wang, W.* “Organocatalytic Asymmetric Michael Addition of 2,4-Pentandione to Nitroolefins” Org. Lett., 2005, 7, 4713-4716. This work has been recognized as Org. Lett. Hot Paper and the most cited papers published on Org. Lett. in 2005.
34) Wang, J.; Li, H.; Mei, Y.; Lou, B.; Xu, D.; Xie, D.; Guo, H.; and Wang, W.* “Direct, Facile Aldehyde and Ketone a-Selenenylation Reactions Promoted by L-Prolinamide and Pyrrolidine Sulfonamide Organocatalysts” J. Org. Chem. 2005, 70, 5678-5687.
35) Wang, W.;* Li, H.; Wang, J. “Pyrrolidine Sulfonamide Promoted Direct, Enantioselective Aldol Reactions of a, a-Dialkyl Aldehydes: Synthesis of Quaternary Carbon-Containing b-Hydroxy Carbonyl Compounds” Tetrahedron Lett., 2005, 46, 5077-5079.
36) Wang, W.;* Li, H.; Wang, J. “Enantioselective, Organocatalytic Mukaiyama-Michael Addition of Silyl Ethers to a, b-Unsaturated Aldehydes” Org. Lett., 2005, 7, 1637-1639.
37) Wang, W.;* Mei, J.; Li, H.; Wang, J. “A Novel Pyrrolidine Imide Catalyzed Direct Formation of a, b-Unsaturated Ketones from Unmodified Ketones and Aldehydes” Org. Lett., 2005, 7, 601-604. This paper is one of the Most Accessed Articles of Org. Lett. in the year of 2005.
38) Wang, W.;* Wang, J.; and Li, H. “Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition Reactions of Aldehydes to Nitrostyrenes” Angew. Chem. Int. Ed., 2005, 44, 1369-1371. This work has been highlighted in Org. Chem. Highlights 2006, January 30. URL: http://www.organic-chemistry.org/Highlights/2006/30JanuaryB.shtm.
39) Wang, W.;* Wang, J.; Li, H. “A Simple and Efficient L-Prolinamide-Catalyzed a-Selenenylation Reactions of Aldehydes,” Org. Lett., 2004, 6, 2817-2820.
40)
Wang, W.;*
Li, H. “An Efficient Synthesis of the Intrinsic Fluorescent Peptide
Labels,
41) Wang, W.;* Li, H.; Wang, J., Liao, L.-X. “Direct, Organocatalytic alpha-Sulfenylation of Aldehydes and Ketones” Tetrahedron Lett., 2004, 45, 8229-8231.
42) Wang, W.;* Wang, J.; Li, H., Liao, L.-X. “A Novel Amine Sulfonamide Organocatalyst for Promoting Direct, Highly Enantioselective a-Aminoxylation Reactions of Aldehydes and Ketones”, Tetrahedron Lett., 2004, 45, 7235-7238. "Top-50 most cited articles" as published in Tetrahedron Lett. 2004-2007.
43) Wang, W.;* Wang, J.; Li, H. “Catalysis of Highly Stereoselective Mannich-Type Reactions of Ketones with a-Imino Esters by a Pyrrolidine Sulfonamide. Synthesis of Unnatural a-Amino Acids,” Tetrahedron Lett., 2004, 45, 7243-7246. "Top-50 most cited articles" as published in Tetrahedron Lett. 2004-2007.
Before joining UNM
44) Zhang, J.; Wang, W.;* Xiong, C.; and Hruby, V.J.* “Efficient and Stereoselective Synthesis of cis-4-Substittued Proline Analogues” Tetrahedron Lett., 2003, 44, 1413-1415.
45) Xiong, C.; Zhang, J.; Davis, P.; Wang, W.; Ying, J.; Porreca, F.; and Hruby, V.J. “Stereoselective Synthesis of Individual Isomers of Leu-Enkephalin Analogues Containing Substituted b-Turn Bicyclic Dipeptide Mimetics” Chem. Commun., 2003, 1598-1599.
46)
Zhang, J.; Xiong, C.; Ying, J.; Wang, W.; Hruby, V.J. “Stereoselective
Synthesis of Dipeptide
b-Turn
Mimeitcs Targeting Melanocortin Receptors: 4,8-Disubstituted Azabicyclo
47)
Wang, W.;
Yang, J.; Ying, J.; Xiong, C.; Zhang, J.; Cai, C.; Hruby, V.J. “Stereoselective Synthesis of Dipeptide
b-Turn
Mimetics: 7-Benzyl and 8-Phenyl Substituted Azabicyclo
48) Wang, W.; Cai, M., Xiong, C.; Zhang, J.; Tevil, D.; Hruby, V.J. “Design and Synthesis of Novel c2-Constrained Phenylalanine, Naphthylalanine, and Tryptophan Analogues and their Use in Biologically Active Melanotropin Peptides” Tetrahedron, 2002, 58, 7365-7374.
49) Zhang, J.; Xiong, C.; Wang, W.; Ying, J.; Hruby, V.J. “Stereoselective Bromination-Suzuki Cross-Coupling of Dehydroamino Acids to Form Novel Reverse-Turn Peptidomimetics: Substituted Unsaturated and Saturated Indolizidinone Amino Acids” Org. Lett., 2002, 4, 4029-4032.
50) Wang, W.; Gao, X.; Wang, B. “Boronic Acid-Based Sensors for Carbohydrates” Curr. Org. Chem, 2002, 6, 1285-1317.
51) Xiong, C.; Wang, W.; Hruby, V.J. “A General Asymmetric Synthesis of syn and anti-b-Substituted Cysteine and Serine Derivatives” J. Org. Chem., 2002, 67, 3514-3517.
52) Wang, W.; Zhang, J.; Xiong, C.; Hruby, V.J. “Design and Synthesis of Hydrophobic, Bulky c2-Constrained Phenylalanine and Naphthylalanine Derivatives” Tetrahedron Lett., 2002, 43, 2137-2140.
53) Xiong, C.; Wang, W.; Hruby, V.J. “Regioselective and Stereoselective Nucleophilic Ring Opening Reactions of a Phenyl Substituted Aziridine: Enantioselective Synthesis of b-Substituted Tryptophan, Cysteine, and Serine Derivatives” J. Org. Chem., 2002, 67, 1339-1402.
54) Wang, W.; Xiong, C.; Zhang, J.; Hruby, V.J. “Practical, Asymmetric Synthesis of Aromatic-Substituted Bulky and Hydrophobic Tryptophan and Phenylalanine Derivatives” Tetrahedron, 2002, 58, 3101-3110.
55)
Wang, W.;
Xiong, C.; Hruby, V.J. “An Efficient Synthesis of
56) Wang, W.; Xiong, C.; Hruby, V.J. “An Efficient Approach to Asymmetric Synthesis of Dipeptide b-Turn Mimetics: Indolizidinone Amino Acids” Tetrahedron Lett., 2001, 42, 3159-3161.
57) Wang, W.; Xiong, C.; Yang, J.; Hruby, V.J. “Practical, Asymmetric Synthesis of Aromatic-substituted Bulky and Hydrophobic Tryptophan Derivatives” Tetrahedron Lett., 2001, 42, 7717-7719.
58) Springsteen, G., Ballard, C.E., Gao, S.; Wang, W.; Wang, B. "The Developemnt of Photometric Sensors for Boronic Acids" Bioorg. Chem., 2001, 29, 259-270.
59) Gao, S.; Wang, W.; Wang, B. "Building Fluorescent Sensors for Carbohydrates Using Templated-directed Polymerizations" Bioorg. Chem., 2001, 29, 308-320.
60) Gao, S.; Wang, W.; Wang, B. “A Novel OsO4-Catalyzed Carbon-Carbon Bond Cleavage Reaction to Give Anthraquinone” Chemistry Lett., 2001, 48-49.
61) Jiang, J.; Wang, W.; Sane, D.C.; Wang, B. “Synthesis of RGD Analogs as Potential Vectors for Targeted Drug Delivery” Bioorg. Chem., 2001, 29, 357-379.
62) Wang, W.; Borchardt, R.T.; Wang, B. “Orally Active Peptidomimetic RGD Analogs that are Glycoprotein IIb/IIIa Antagonists” Curr. Med. Chem., 2000, 7, 437-453.
63) Wang, W.; Springsteen, G.; Gao, S.; Wang, B. "The First Fluorescent Sensor for Boronic and Boric Acids with Sensitivity at Sub-micromolar Concentrations" Chem. Comm. 2000, 1283-1284.
64) Wang, W.; Camenisch, G.; Sane, D.C.; Zhang, H.; Hugger, E.; Wheeler, G.L.; Borchardt, R.T.; Wang, B."The Use of Prodrug Strategy to Optimize the Oral Absorption of RGD Peptidomimetics” J. Controlled Release, 2000, 65, 245-251.
65) Shan, D.; Zheng, A.; Ballard, C.E.; Wang, W.; Borchardt, R.T.; Wang, B. "A Facilitated Cyclic Ether Formationand its Potential Application in Solid-phase Peptide and Organic Synthesis" Chem. Pharm. Bull. 2000, 48, 238-244.
66) Wang, W.; Gao, S.; Wang, B. "Building Fluorescent Sensors by Template Polymerization: The Preparation of a Fluorescent Sensor for D-Fructose" Org. Lett., 1999, 1, 1209-1212.
67) Wang, W.; Jiang, J.; Ballard, C.E.; Wang, B. "Prodrug Approaches to the Improved Delivery of Peptide Drugs" Curr. Pharm. Design, 1999, 5, 265-287.
68) Liao, Y.; Wang, W.; Wang, B. "Building Fluorescent Sensors by Template Polymerization: The Preparation of a Fluorescent Sensor for L-Tryptophan" Bioorg. Chem., 1999, 27, 463-476.
69) Wang, B.; Nimkar, K.; Wang, W.; Zhang, H.; Shan, D.; Gudmundsson, O.S.; Gangwar, S.; Siahaan, T.; Borchardt, R.T. "Synthesis and Evaluation of the Physicochemical Properties of Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides Using Coumarinic Acid and Phenylpropionic Acid Linkers" J. Peptide Res. 1999, 53, 370-382.
70)
Borchardt, R.T.; Camenisch, G.; Hugger, E.; Wang, W.; Sane, D.C.;
Wheeler, G.L.; Cheng, C.-P.; Wang, B. " Prodrug Strategies to Improve the Oral
Absorption of Peptide Mimetics" Polymer Preprints, 1999, 40
71) Zheng, A.; Wang, W.; Zhang, H.; Wang, B. "Two New Improved Approaches to the Synthesis of Coumarin-Based Prodrugs" Tetrahedron 1999, 55, 4237-4254.
72) Gudmundsson, O.S.; Pauletti, G.M.; Wang, W.; Shan, D.; Zhang, H.; Wang, B.; Borchardt R.T. "Coumarin-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeability" Pharm. Res. 1999, 16, 7-15.
73) Wang, B.; Wang, W.; Camenisch, G.P.; Elmo, J.; Zhang, H.; Borchardt, R.T. "Synthesis and Evaluation of Novel Coumarin-Based Esterase-Sensitive Cyclic Prodrugs of Peptidomimetic RGD Analogs with Improved Membrane Permeability" Chem. Pharm. Bull. 1999, 47, 90-95.
74) Liao, Y.; Wang, W.; Wang, B. "Enantioselective Polymeric Transporters of D-Tryptophan Prepared Using Molecular Imprinting Techniques" Bioorg. Chem. 1998, 26, 309-322.
75) Camenisch, G.P.; Wang, W.; Wang, B.; Borchardt, R.T. "A Comparison of the Bioconversion Rates and the Caco-2 Cell Permeation Characteristics of Coumarin-Based Cyclic Prodrugs and Methylester-Baesd Linear Prodrugs of RGD Peptidomimetics" Pharm. Res. 1998, 15, 1174-1181.
76) Wang, B.; Zhang, H.; Zheng, A.; Wang, W. "Coumarin-Based Prodrugs. Part 3: Structural Effects on the Release Kinetics of Esterase-sensitive Prodrugs of Amines" Bioorg. Med. Chem. 1998, 6, 417-426.
77) Benbrook, D.M.; Madler, M.M.; Spruce, L.W.; Birckbichler, P.J.; Nelson, E.C.; Subramanian, S.; Weerasekare, G.M.; Gale, J.B.; Patterson, M.K.Jr.; Wang, B.; Wang, W.; Lu, S.; Rowland, T.C.; DiSivestio, P.; Berlin, K.D. "Biologically Active Heteroarotinoids Exhibiting Anticancer Activity and Decrease Toxicity" J. Med. Chem. 1997, 40, 3567-3583.
78) Wang, B.; Wang, W.; Zhang, H.; Shan, D.; Smith, T.D. "Coumarin-Based Prodrugs 2. Synthesis and Bioreversibility Studies of an Esterase-sensitive Cyclic Prodrug of DADLE, an Opioid Peptide" Bioorg. Med. Chem. Lett. 1996, 6, 2823-2826.
79) Wang, B.; Zhang, H.; Wang, W. "Chemical Feasibility Studies of a Potential Coumarin-Based Prodrug System" Bioorg. Med. Chem. Lett. 1996, 6, 945-950.
Articles Appearing in Chapters in Edited Volumes:
1) Wang, W.; Zheng, A.; Liu, S.; Wang, B. “Solid Supports, Linkers and Solid-Phase Supported Reagents in Chemical Library Synthesis” in Combinatorial Approaches to Drug Lead Discovery, Liu, G.; Xiao, X.; Wang, J. Eds. page 88~122, Science Press, China, 2003.
2) Gao, S.; Wang, W.; Wang, B. “Molecularly Imprinted Polymers as Recognition Elements in Optical Sensors” in Optical Sensors, Yan, M.; Ramström, O. Eds., Marcel Dekker, Inc., 2002, invited book chapter.
3) Wang, W.; Xiong, C.; Hruby, V.J. “Two Novel and Efficient Approaches to Synthesis of Enantiopure Dipeptide b-Turn Mimetics: Indolizidinone Amino Acids” In Peptides: The Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 30-31.
4) Cai, C.; Wang, W.; Xiong, C.; Soloshonok, V.A.; Cai, M.; Hruby, V.J. “Synthesis of Novel b and g-Substituted Prolines for Conformation-Activity Relationship Studies of the a-MSH Analogues MT-II” In Peptides: The Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 20-21.
5) Xiong, C.; Wang, W.; Cai, C.; Hruby, V.J. “The Novel Asymmetric Synthesis of b-Fuctionalized Phenylalanine Derivatives” In Peptides: The Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 24-25.
6) Xiong, C.; Wang, W.; Hruby, V.J. “The General Asymmetric Synthesis of Syn and Anti- β-Substituted Cysteine and Serine Derivatives” In Peptides: The Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 22-23.
7) Wang, W.; Borchardt, R.T.; Sane, D.C.; Wang, B. “Delivering Peptides and Peptidomimetics across Membrane Barriers. A Prodrug Approach” In Peptides for New Millennium: Proceeding of the 16th American Peptide Symposium, G.B. Fields, J.P. Tam, G. Barany, Editors. Kluwer Academic Publishers, the Netherlands, 2000, 214-216.
8) Gudmundsson, O.S.; Bak, A.; Wang, W.; Shan, D.; Zhang, H.; Friis, G.J., Wang, B.; Borchardt, R.T. "Prodrug Strategies to Enhance the Permeation of Opioid Peptides through the Intestinal Mucosa" Peptide and Protein Drug Delivery, S. Frokjer, L. Christruecrd, P. Krogsgard, Editors. Munksgaard, Denmark, 1998, p 259-269.
9) Wang, B.; Shan, D.; Wang, W.; Zhang, H.; Gudmundsson, O.S.; Borchardt, R.T. "Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymatic Stability" Methods in Molecular Medicine Kazmierski, W.; Walker, J.M. Editors. Humana Press Inc., Totowa, NJ. 1998, 71-85.
Patents
1)
Wang, W.;
Wang, J.; Li, H. “Organocatalysis and Methods of Use
in Chemical Synthesis” WO 2006007586
2)
Fan, Y.; Gao, W.; Gray, N.S.; Hinterding, K.; Lefebvre, S.; Mi,
Y.; Nussbaumer, P.; Pan, S.; Wang, W.; Zecri, F.; Perez, L. B.; La
Montagne, K.R.; Ettmayer, P.
Invited Presentations at Professional Meetings:
Invited Talks in Universities and Institutes
1) “TBA” Department of Chemistry and Biological Chemistry, University of Southern California, Los Angeles, CA, May 30, 2008.
2) “TBA” Department of Chemistry and Biological Chemistry, University of California, Los Angeles, CA, May 29, 2008.
3) “TBA” Department of Chemistry and Biological Chemistry, University of California, Santa Cruz, CA, May 19, 2008.
4) “TBA” Department of Chemistry, University of New Orleans, New Orleans, Louisiana, April 4, 2008.
5) “TBA” Department of Chemistry, Texas A & M University, College Station, Texas, March 20, 2008.
6) “TBA” Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, March 18, 2008.
7) “TBA” Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, March 12, 2008.
8) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, Washington State University Pullman, Washington, February 25, 2008.
9) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, University of Colorado, Boulder, Colorado, October 30, 2007.
10) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, Colorado State University, Fort Collins, Colorado, October 29, 2007.
11) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Departments of Chemistry and Medicinal Chemistry, University of Toledo, Toledo, Ohio, October 11, 2007.
12) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, Wayne State University, Detroit, Michigan, October 10, 2007.
13) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, University of Arizona, Tucson, October 4, 2007.
14) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, University of Texas at Austin, Austin, Texas, September 19, 2007.
15) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, University of Houston, Houston, Texas, September 18, 2007.
16) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, Peking University, Beijing, China, June 15, 2007.
17) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, June 7, 2007.
18) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, East China Normal University, Shanghai, China, June 6, 2007.
19) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China, June 6, 2007.
20) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, Central China Normal University, Wuhan, China, May 31, 2007.
21) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” Department of Chemistry, Shanghai Normal University, Shanghai, China, May 29, 2007.
22) “Organocatalytic Enantioselective Reactions and Their Applications in Organic Synthesis” Department of Chemistry, New Mexico State University, Las Cruces, New Mexico, April 19, 2007.
23) “Organocatalytic Enantioselective Reactions and Their Applications in Organic Synthesis” Department of Chemistry and Biochemistry, West Virginia University, Morgantown, West Virginia, March 21, 2007.
24) “Organocatalytic Enantioselective Reactions and Their Applications in Organic Synthesis and Drug Discovery” Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, January 24, 2007.
25) “Organocatalytic, Enantioselective Approach to Medicinally Interesting Chiral Molecules” College of Pharmacy, University of Kentucky, Lexington, Kentucky, October 20, 2006.
26) “Organocatalytic, Enantioselective Approach to Medicinally Interesting Chiral Molecules” Merck Research Laboratory, Rahway, New Jersey, November 15, 2006.
27) “Biomimetic Approach to Design Novel Small Organic Molecules as Catalysts for Asymmetric Organic Transformations” Department of Chemistry, University of Tampa, Florida, March 31, 2006.
28) “Biomimetic Approach to Design Novel Small Organic Molecules as Catalysts for Asymmetric Organic Transformations” Department of Chemistry, University of South Florida, Florida, March 30, 2006.
29) “Biomimetic Approach to Design Novel Small Organic Molecules as Catalysts for Asymmetric Organic Transformations” Department of Chemistry, Georgia State University, Atlanta, GA, March 25, 2006.
30) “Biomimetic Approach to Design Novel Small Organic Molecules as Catalysts for Asymmetric Organic Transformations” Department of Chemistry and Biochemistry, University of Texas at San Antonio, TX, February 24, 2006.
31) “Biomimetic Approach to Design Novel Small Organic Molecules as Catalysts for Asymmetric Organic Transformations” College of Pharmacy, Fudan University, Shanghai, China, December 20, 2005.
32) “Biomimetic Approach to Design Novel Small Organic Molecules as Catalysts for Asymmetric Organic Transformations” Department of Chemistry, Fudan University, Shanghai, China, December 22, 2005.
33)
“Biomimetic
Approach to Design Small Organic Molecules as
34) “New Strategy in Organic Synthesis. Development of Novel Organocatalysts for Asymmetric Organic Transformations” Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, December 18, 2004.
35) “New Strategy in Organic Synthesis. Development of Novel Organocatalysts for Asymmetric Organic Transformations” Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China, December 20, 2004.
36) “New Strategies in Organic Synthesis. Development of Novel Organocatalysts for Asymmetric Organic Transformations” Department of Chemistry, Case Western Reserve University, Cleveland, OH, October 11-13, 2004.
37) “New Strategies in Organic Synthesis. Development of Novel Organocatalysts for Asymmetric Organic Transformations” Department of Chemistry, University of Akron, Akron, OH, October 11-13, 2004.
38) “Chemical Approaches to Biological Problems” College of Pharmacy, University of New Mexico, Albuquerque, NM, March 8, 2004.
39)
“Novel
Strategies for Development of Peptide and Peptidomimetic-based Drugs”, the
Laboratory of Medicinal Chemistry, National Cancer Institutes
40) “Novel Strategies for Development of Peptide and Peptidomimetic-based Drugs”, Department of Chemistry, Northern Illinois University, DeKalb, Illinois, December 2-3, 2002.
41) “Novel Strategies for Development of Peptide and Peptidomimetic-based Drugs”, Department of Chemistry, University of Manitoba, Winnipeg, Canada, November 25-26, 2002.
42) “Novel Strategies for Development of Peptide and Peptidomimetic-based Drugs”, Division of Medicinal Chemistry and Natural Product, College of Pharmacy, University of Iowa, Iowa City, Iowa, November 14-15, 2002.
Invited Presentations in Professional Conferences
1) Title “TBA” The 10th International Symposium for Chinese Organic Chemists (ISCOC-10) and 7th International Symposium for Chinese Inorganic Chemists (ISCIC), Shanghai, China, July 27-31, 2008.
2) Title “TBA” Gordon Research Conference on Organic Reactions and Process, , Bryant University in Smithfield, Rhode Island, July 13-18, 2008.
3) “TBA” The ACS Rocky Mountain/NW Regional Meeting, Park City, Utah, June 15-18, 2008.
4) “Organocatalytic Enantioselective Cascade Reactions, A Powerful Tool for the Efficient Assembly of Complex Molecular Architectures” The 63rd Southwest Regional American Chemical Society Meeting, Lubbock, Texas, November 4-7, 2007.
5) “Organocatalytic Enantioselective Cascade Reactions” The 3rd Sino-American Organic Chemistry Symposium, Wuhan, China, June 1-2, 2007.
6) “Chiral Pyrrolidine Sulfonamide Promoted Enantioseelctive Organic Reaction” The 2006 Lanzhou International Symposium On Organic Chemistry and Medicinal Chemistry, Lanzhou University, Lanzhou, China, July 9-11, 2006.
7) “Chiral Pyrrolidine Sulfonamide Promoted Enantioselective Organic Reactions”, The 2nd Sino-US Chemistry Professor Conferences, Shanghai, China, July 8-9, 2006.
8)
“Chiral
Pyrrolidine Sulfonamide Promoted Enantioselective Organic Reactions”
The 16th IUPAC's International Conference on
Organic Synthesis
Contributed
1) Li, H.; Wang, J.; Zu, L.; Xie, H.-X.; Jiang, W.; and Wang, W. “Enantioselective Organocatalytic Tandem Michael-Aldol Reactions” The 63rd Southwest Regional American Chemical Society Meeting, Lubbock, Texas, November 4-7, 2007 (poster and oral).
2) Xie, H.-X.; Li, H.; Wang, J.; Zu, L.; Jiang, W.; and Wang, W. “Organocatalytic Enantioselective Cyclopropanations between a, b-Unsaturated Aldehydes and Bromomalonates” The 63rd Southwest Regional American Chemical Society Meeting, Lubbock, Texas, November 4-7, 2007 (poster and oral).
3) Jiang, W.; Li, H.; Zu, L.; Xie, H.-X.; and Wang, W. “Enantioselective Organocatalytic Tandem Michael-Aldol Reactions: One-Pot Synthesis of Chrial Cyclopentenes” The 63rd Southwest Regional American Chemical Society Meeting, Lubbock, Texas, November 4-7, 2007 (poster and oral).
4) Zu, L.; Jiang, W.; Li, H.; Xie, H.-X.; Jiang, W.; and Wang, W. “Tandem Michael-Aldol Reactions Promoted by Hydrogen-Bonding Mediated Catalysis” The 63rd Southwest Regional American Chemical Society Meeting, Lubbock, Texas, November 4-7, 2007 (poster and oral).
5) Jiang, W.; Fu, Q.-Q.; Fang, H.-Y.; Ho, J.; and Wang, W. “A Highly Selective Fluorescent Probe for Facile Detection of Thiophenols” The 63rd Southwest Regional American Chemical Society Meeting, Lubbock, Texas, November 4-7, 2007 (poster and oral).
6)
Zu, L.; Wang, J.; Li, H.; and Wang, W. “A recyclable
fluorous
7)
Wang, J.; Li, H.; Zu, L.; and Wang, W. “Enantioselective
organocatalytic Michael addition of N-heterocycles to nitroolefins and enones”
the 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14,
2006
8)
Li, H.; Wang, J.; Zu, L.; and Wang, W. “Organocatalytic
enantioselective Michael addition of thioacetic to nitroolefins and enones” the
232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006
9)
Li, H.; Mei, Y.; Wang, J.; and Wang, W. “A novel pyrrolidine imide-catalyzed
direct formation of alpha, beta-unsaturated ketones from unmodified ketones and
aldehydes” the 232nd ACS National Meeting, San Francisco, CA, United States,
Sept. 10-14, 2006
10)
Li, H.; Wang, J.; Zu, L.; and Wang, W. “Direct, pyrrolidine
sulfonamide-promoted enantioselective aldol reactions of alpha, alpha-dialkyl-aldehydes:
Synthesis of quaternary carbon-containing beta-hydroxy carbonyl compounds” the
232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006
11)
Wang, J.; Li, H.; Zu, L.; and Wang, W. “
12)
Wang, J; Li, H; Zu, L and
Wang, W.
“Development
of Organocatalytic Enantioselective Michael Addition Reactions of Nitroolefins
and Enones for Formation of New C-O, S and N Bonds” Gordon Research Conferences
on Stereochemistry, June 18-23, 2006,
Salve Regina University,
Newport, RI
13)
Wang, J.; Li, H.; Zu, L.-S.; Wang, W. “Binaphthyl-based
Bifunctional Organocatalyst-Promoted Enantioselective Morita-Baylis-Hillman
Reactions” the 231th ACS National Meeting, Atlanta, GA, March 26-30, 2006
14)
Wang, J.; Li, H.; Zu, L.-S.; Wang, W. “Binaphthyl-based
Bifunctional Organocatalyst-Promoted Enantioselective Michael Addition of
1,3-Diketones to Nitroolefins” the 231th ACS National Meeting, Atlanta, GA,
March 26-30, 2006
15)
Wang, J.; Li, H.; Zu, L.-S.; Wang, W. “Chiral
Pyrrolidine Sulfonamide-Promoted Direct, Highly Enantio- and Diastereoselective
Michael Addition of Ketones to Enones” the 231th ACS National Meeting, Atlanta,
GA, March 26-30, 2006
16)
Wang, W.;
Wang, J.; Li, H. “Pyrrolidine Sulfonamide
Promoted Direct, Highly Enantioselective Michael Addition Reactions of Aldehydes
and Ketones to Nitrostyrenes”, Gordon Research Conferences-Organic Reactions &
Processes, Smithfield, July 31 to August 5, 2005
17) Wang, W.; Wang, J.; Li, Hao “Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition Reactions of Aldehydes and Ketones to Nitrostyrenes and Applications for Formal Synthesis of Montanine Alkaloids” the 229th ACS National Meeting, San Diego, CA, March 13-17, 2005 (oral).
18)
Wang, W.;
Wang, J.; Li, Hao “Catalysis of Highly
Stereoselective Mannich-type Reactions of Aldehydes and Ketones with alpha-Imino
Esters by a Pyrrolidine Sulfonamide: Synthesis of Unnatural alpha-Amino Acids",
the 229th ACS National Meeting, San Diego,
CA, March 13-17, 2005
19)
Wang, W.;
Wang, J.; Li, Hao “Simple, Efficient
Organocatalytic alpha-Selenenylation and alpha-Sulfenylation Reactions of
Aldehdyes and Ketones",
the 229th ACS National Meeting, San Diego,
CA, March 13-17, 2005
20) Wang, W.; Xiong, C.; Hruby, V.J. “Two Novel and Efficient Approaches to Synthesis of Enantiopure Dipeptide b-Turn Mimetics: Indolizidinone Amino Acids” presented at the 17st American Peptide Symposium/2nd International Peptide Symposium, June 9-14, 2001, San Diego, CA (poster).
21) Cai, C.; Wang, W.; Xiong, C.; Soloshonok, V.A.; Cai, M.; Hruby, V.J. “Synthesis of Novel b and g-Substituted Prolines for Conformation-Activity Relationship Studies of the a-MSH Analogues MT-II” presented at the 17st American Peptide Symposium/2nd International Peptide Symposium, June 9-14, 2001, San Diego, CA (poster).
22) Xiong, C.; Wang, W.; Cai, C.; Hruby, V.J. “The Novel Asymmetric Synthesis of b-Fuctionalized Phenylalanine Derivatives” presented at the 17st American Peptide Symposium/2nd International Peptide Symposium, June 9-14, 2001, San Diego, CA (poster).
23) Xiong, C.; Wang, W.; Hruby, V.J. “The General Asymmetric Synthesis of Syn and Anti- β-Substituted Cysteine and Serine Derivatives” presented at the 17st American Peptide Symposium/2nd International Peptide Symposium, June 9-14, 2001, San Diego, CA (poster).
24) Wang, W.; Xiong, C.; Hruby, V.J. “Efficient and Asymmetric Synthesis of Dipeptide b-Turn Mimetics: Indolizidinone Amino Acids” presented at the 221st American Chemical Society National Meeting, April 1-4, 2001, San Diego, CA (poster).
25) Xiong, C.; Wang, W.; Hruby, V.J. “Diastereoselective Synthesis and Ring Opening of N-Phthalimidoaziridines: Synthesis of Substituted Hydrazino Acid Derivatives” presented at the 221st American Chemical Society National Meeting, April 1-4, 2001, San Diego, CA (poster).
26) Wang, W.; Gao, S.; Springsteen, G.; Wang, B. “Design and Synthesis of the First Fluorescent Sensors for Boric and Boronic Acids” presented at the Pacificchem, December 14-19, 2000, Honolulu, Hawaii (poster).
27) Wang, W.; Gao, S.; Springsteen, G.; Wang, B. “Design and Synthesis of the First Fluorescent Sensors for Boric and Boronic Acids” presented at the 220th National Meeting, August 20-24, 2000, Washington, D.C. (poster).
28) Gao, S.; Wang, W.; Wang, B. “A New OsO4-Mediated Carbon-Carbon Bond Cleavage Reaction Leading to the Formation of Anthraquinone” presented at the 220th National Meeting, Agugust 20-24, 2000, Washington, D.C. (poster).
29) Borchardt, R.T.; Camenisch, G.; Hugger, E.; Wang, W.; Sane, D.C.; Wheller, G.L.; Cheng, C.P.; Wang, B. "The Use of Prodrug Strategies to Optimize the Oral Absorption of RGD Peptide Mimetics" Presented at the 9th International Symposium on Recent Advances in Drug Delivery Systems, February 22-24, 1999, Salt Lake City, UT (poster).
30) Borchardt, R.T.; Camenisch, G.; Hugger, E.; Wang, W.; Sane, D.C.; Wheller, G.L.; Cheng, C.P.; Wang, B. "Prodrug Strategies to Improve the Oral Absorption of Peptide Mimetics" Presented in the Polymer Chemistry Division at the 217th American Chemical Society National Meeting, March 21-25, 1999, Anaheim, CA (poster).
31) Zheng, A.; Shan, D.; Wang, W.; Borchardt, R.T.; Wang, B. "A "Trimethyl Lock"-Facilitated Cyclic Formation" Presented in the Organic Chemistry Division at the 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, MA (poster).
32) Liao, L.; Wang, W.; Wang, B. "Enantioselective Polymeric Transporters of D-Tryptophan Prepared Using Molecular Imprinting Techniques" Presented in the Organic Chemistry Division at the 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, MA (poster).
33) Wang, W.; Sane, D.C.; Bai, S.A.; Chang, C.P.; Borchardt, R.T.; Wang, B. "Synthesis and Biological Evaluation of a Coumarin-Based, Esterase-sensitive Cyclic Prodrug of an Antithrombotic RGD Analog: MK-383" Presented in the Medicinal Chemistry Division at the 216th American Chemical Society National Meeting, August 23-27, 1998, Boston, MA (poster).
34) Wang, W.; Sane, D.C.; Bai, S.A.; Chang, C.P.; Wang, B. "Synthesis and Biological Evaluation of a Coumarin-Based, Esterase-sensitive Cyclic Prodrug of an Antithrombotic RGD Analog: MK‑383" Presented at the 26th National Medicinal Chemistry Symposium, June 14-18, 1998, Richmond, VA (poster).
35) Wang, B.; Liao, Y.; Wang, W. "Enantiospecific Artificial Receptors and their Potential Applications in Separation and Analytical Chemistry" Presented at the 31st Annual Higuchi Research Seminar, March 8-11, 1998, Lake Ozark, MO (poster).
36) Camenisch, G.P.; Wang, W.; Wang, B.; Borchardt, R.T. "Esterase-Sensitive Coumarin-Based Prodrugs of RGD Mimetics Having Enhanced membrane Permeability" Presented at the 1997 American Association of Pharmaceutical Scientists National Meeting, November 2-6, 1997, Boston, MA (poster).
37) Gudmundsson, O.S.; Pauletti, G.M.; Wang, W.; Shan, D.; Zhang, H.; Wang, B.; Borchardt, R.T. "Novel Prodrugs of Opioid Peptides Which Exhibit Increased Metabolic Stability and Enhanced Cellular Permeability" Presented at the 1997 American Association of Pharmaceutical Scientists National Meeting, November 2-6, 1997, Boston, MA (poster).
38) Gudmundsson, O.S.; Jois, S.D.S.; Vander Velde, D.G.; Shan, D.; Wang, W.; Zhang, H.; Wang, B.; Borchardt, R.T. "The Effect of Conformation on the Membrane Permeabilities of Coumarin-Based Cyclic Prodrugs of Opioid Peptides" Presented at the 1997 American Association of Pharmaceutical Scientists National Meeting, November 2-6, 1997, Boston, MA (poster).
39) Wang, W.; Camenisch, G.P.; Zhang, H.; Borchardt, R.T.; Wang, B. "Synthesis of Coumarin-Based Cyclic Prodrugs of Peptidiomimetic Fibrinogen Antagonists" Presented in the Medicinal Chemistry Division at the 214th American Chemical Society National Meeting, September 7-11, 1997, Las Vegas, NV (poster).
40) Zhang, H.; Wang, W.; Zheng, A.; Wang, B. "Coumarin-Based Prodrugs of Amines. Structural Effects on the Release Kinetics" Presented in the Medicinal Chemistry Division at the 213th American Chemical Society National Meeting, April 13-17, 1997, San Francisco, CA (poster).
41) Zhang, H.; Wang, W.; Shan, D.; Wang, B. "Bioreversible Cyclic Prodrugs of Peptides. Evaluation of the Release Kinetics" Presented in the Medicinal Chemistry Division at the 213th American Chemical Society National Meeting, April 13-17, 1997, San Francisco, CA (poster).
42) Shan, D.; Wang, W.; Zhang, H.; Zheng, A.; Wang, B. "Synthesis of Novel Coumarin-Based Cyclic Prodrugs of Peptides and Peptide Mimetics" Presented in the Medicinal Chemistry Division at the 213th American Chemical Society National Meeting, April 13-17, 1997, San Francisco, CA (poster).
43) Wang, W.; Wang, B. "Development of Potential Antimicrobial Agents Targeted on the Shikimate Pathway" Presented at the 9th Annual Oklahoma Health Research Conference, April 11, 1996, Oklahoma City, OK (poster).
44) Wang, B.; Wang, W.; Liu, S.; Borchardt, R.T. "Development of a Redox-Sensitive Protecting Group Using a Facilitated Lactonization Reaction: Protection of Hydroxyl Groups" Presented in the Organic Chemistry Division at the 210th American Chemical Society National Meeting, August 20‑24, 1995, Chicago, IL (poster).
45) Wang, B.; Wang, W. "Development of a Redox-Sensitive Protecting Group Using a Facilitated Lactonization Reaction: Protection of Hydroxyl Groups" Presented during the penta-sectional meeting of American Chemical Society, Oklahoma Section, 1994 (poster).
46)
Wang, W.;
Gu, K.; Ji, R. "The Synthesis of
47)
Wang, W.;
Gu, K.; Ji, R. "The Synthesis of
Graduate Students Supervised
Current
Hao Li, August 2003 to present
Liansuo Zu, August 2004 to present
Wei Jiang, August 2004 to present
Hexin Xie, July 2006 to present
Dominic K. Kersi, August 2006 to present
Benjamin Njus, August 2007 to present
Former
Jian Wang, August 2003 to June 2007, graduated with Ph.D. degree
Post-doc with Prof. Peter G. Schultz in the Scripps Research Institute
Post-docs:
Current
Dr. Guixia Liu, November 2007 to present
Dr. Tangzhi Zhang, November 2007 to present
Former
Dr. Qingquan Fu, October 2006 to September 2007
Professor, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences
Undergraduate Students Supervised
Nicholas Card, Spring 2004, Synthesis of XIAP Inhibitors
Jeff Kellgwood, Spring 2005, Organocatalysis
Timiyin M E-Nunu, Summer 2005, Organocatalysis
Michael G. Fulton, Summer 2005, Fluorescence Sensors
Lora D Heikkinen, Summer and Fall 2005, Organocatalysis
Brandi N. Kimble, Summer 2007, Organocatalysis
Jordan A. Monteverdi, Summer 2007, Organocatalysis
Hien D. Vu, Summer 2007, Organocatalysis
Bernadette R. Aragon, Fall 2007, Organocatalysis
Hanine R. Oueis, Fall 2007, Organocatalysis