Zhen Huang's Laboratory (黄震 Lab)

 

Prof. Zhen Huang (University Distinguished Professor Awardee & Georgia State Distinguished Cancer Scholar (GCC)

Lab Members

More Lab Pictures

Research

Enzymology

Teaching Chemistry

Chinese-American Chemistry & Chemical Biology Professors Association (CAPA)

 

 

The Third International Conference on Chemical and Structural Biology of Nucleic Acids and Proteins for Novel Drug Discovery (Sep. 13-15, 2013, Atlanta, USA)  2013 第届核酸与蛋白质化学及结构生物学国际大会

                                                  Click here for the Conference Schedule and Abstract Book

 

 

 

 

The Second International Conference on Chemical and Structural Biology of Nucleic Acids and Proteins for Novel Drug Discovery (May 19-22, 2012, Beijing, China)  2012 第二届核酸与蛋白质化学及结构生物学国际大会

(websites: http://meeting.sciencenet.cn/cinfo.aspx?cid=2657 and http://iccsb.life.tsinghua.edu.cn/)

                                                                                    Click here for the Abstract Book

 

 

 

The 1st International Conference on Chemical and Structural Biology of Nucleic Acids and Proteins for Novel Drug Discovery (June 12-14, 2011, Beijing, China) 2011 第届核酸与蛋白质化学及结构生物学国际大会

Click here for the Abstract Book

 

 

Research Interests:

The research interests of my laboratory are at the interface of organic chemistry, biochemistry, molecular biology, biophysical chemistry, and structural biology. Since nucleic Acids play the most important roles in living organisms, to discover how nucleic acids behave in vitro and in vivo is essential to understand their biochemical and biological  properties, to design and develop drugs and therapeutics for fighting cancers, viruses and other diseases, and to diagnose and understand diseases at the nucleic acid (or genetic) level or the molecular level.

 

The students who join in my laboratory will receive opportunities to learn Synthetic Organic Chemistry, Medicinal Chemistry, Therapeutics Design and Drug Discovery, Biochemistry, Bio-analytical Chemistry, RNA MicroChip/MicroArray, Disease Detection, Structural Chemistry, and techniques in Physical Chemistry, Molecular Biology and Structural Biology.

 

 

Positions Open for Graduate Students & Post-doctors with Crystallographic Background

 

 

Research Project I:

       Chemical and Enzymatic Synthesis of Anti-HIV/Virus/Anti-cancer Drugs and Selenium-Derivatized Nucleic Acids (SeNA) for X-ray Crystallography. The Se-derivatization dramatically facilitates both Crystallization & Phasing of the bio-macromolecules.

 

Figure 1. Synthesis of 2-Se-T phosphoramidite (6) and Se-DNA (7). Journal of American Chemical Society, 2010, 132, 21202121.

 

 

 

 

                           

Figure 2. The global and local structures of the 4-Se-T DNA [(5-G-dUSe-G-SeT-ACAC-3)2]. (A) The duplex structure of the modified DNA (2NSK, in cyan) is superimposed over the native (1DNS, in pink). (B) The comparison of the modified (in green) and native (in cyan) local T4 structures. (C) The Se-base pair of T4-A5 with the experimental electron density.  Journal of Am. Chem. Soc., 2007, 129, 4862-4863.

 

 

 

 

Research Project II: RNA MicroArray and MicroChip Technologies

 

 

 

 

 

 

 

 

 

 

Figure 3. This RNA MicroChip/MicroArray Technology will be a direct, simple, rapid, selective, sensitive & cost-effective detection & quantification system. ChemBioChem, accepted, 2010, 11, 13781382.

 

 

Contact Information and Mailing Address:

Zhen Huang, Ph.D.

Professor of Chemistry and Chemical Biology (University Distinguished Professor Awardee)
Department of Chemistry and Department of Biology
Georgia State University
P.O. Box 4098
Atlanta, Georgia 30302-4098, USA

Office Location: 547 NSC

Phone: (404) 413-5535 (Office)
               (404) 413-5534 (Lab)
Fax:       (404) 413-5505

Email: Huang@gsu.edu
           or
chezh@langate.gsu.edu