Gangli Wang Assistant Professor, Analytical Chemistry Ph.D. University of North Carolina-Chapel Hill (2004) Dr. Gangli Wang Department of Chemistry Georgia State University P.O. Box 4098 Atlanta, Georgia 30302-4098 Phone:  404-413-5507 Lab Phone:  404-413-5542 Fax:  404-413-5505 Office:  420 Natural Science Center Email:  glwang@gsu.edu

Research Interests
Bioanalytical chemistry; biosensors, bioimaging with functional nanomaterials

Research Projects

Single Bioactivity Sensing by Functional Nanopore Platforms

The long term goal is to develop an analytical platform using functionalized nanopore devices to investigate biological and physiological single-molecular events.  Monoamine neurotransmitters carry neuron signal and are of vital importance for physiological and cognitive functions.  The electrochemical active monoamines can be directly detected by electrochemical measurements using the conical shaped glass nanopore electrodes or membranes that are created by electrochemical etching of Pt nanodisk electrodes embedded in glass.  With the orifice dimension comparable to single transporter protein or single vesicle and the surface being functionalized, these nanopores can provide thermodynamic and kinetic information of single transport event not accessible with currently used ensemble averaged methods.  The knowledge can significantly improve our understanding of the transport process and lead to potential treatments.

Bi-functional Nanomaterials:  Gold Monolayer Protected Clusters (AuMPC) and Magnetic Nanoparticles (MagNP)

Materials with nanosized dimension have interesting properties resulted from quantum confinement effect.  The ability to “program” self-assembled nanosized materials attracts extensive interests among scientists and engineers.  It is even more challenging to create asymmetric building blocks and structures.   AuMPCs, considered as large-molecules, have signature optical and electrochemical properties associated with the size and composition.  These properties could render the complex useful in extensive applications in materials, biological and medical sciences.  MagNPs can be used as a template to create and separate the asymmetric assemblies of these two types of materials.  The final magnet-guided complex with strong near IR photoluminescence (from the AuMPC) can potentially be used for targeted labeling, deep tissue imaging and cancer treatment.

Single Electron Tunneling Measurements of Monolayer Protected Clusters on a non-conductive SiO₂ surface with Electron Force Microscopy
Collaborator: Dr. Clayton C. Williams, Physics Department, University of Utah

The research in my group focuses on the development and application of analytical methods targeting biological and physiological studies.  The students will be exposed to various analytical techniques such as electrochemistry, spectroscopy and microscopy (UV-Vis & Fluorescence), separation of nanomaterials, surface chemistry and nanodevice fabrication.

Selected Publications

1. Wang, G.; Bohaty, A.; Zharov, I. and White, H. S. Photon-Gated Transport at the Glass Nanopore Electrode, J. Am. Chem. Soc. 2006, 128, 13553.
   
   
2. Wang, G.; Zhang, B. Wayment, J. R.; Harris, J. M. and White, H. S. Electrostatic-Gated Transport in Chemically Modified Glass Nanopore Electrodes, J. Am. Chem. Soc. 2006, 128, 7679.
   
   
3. Wang, G.; Guo, R.; Kalyuzhny, G.; Choi, J.-P. and Murray, R. W. NIR Luminescence Intensities Increase Linearly with Proportion of Polar Thiolate Ligands in Protecting Monolayers of Au₃₈ and Au₁₄₀ Quantum Dots, J. Phys. Chem. B 2006, 110, 20282.
   
   
4. Guo, R.; Song, Y.; Wang, G.; Murray, R. W. Does Core Size Matter in the Kinetics of Ligand Exchanges of Monolayer-Protected Au Clusters? J. Am. Chem. Soc. 2005, 127, 2752.
   
   
5. Wang, G.; Huang, T.; Murray, R. W.; Menard, L.; Nuzzo, R. G. Near-IR Luminescence of Monolayer Protected Metal Clusters, J. Am. Chem. Soc. 2005, 127, 812.
   
   
6. Lee, D.; Donkers, R. L.; Wang, G.; Harper, A. S. and Murray, R. W. Electrochemistry and Optical absorbance and luminescence of Molecule-like Au38 Nanoparticles. J. Am. Chem. Soc. 2004, 126, 6193.
   
   
7. Wang, G. and Murray, R. W. Controlled Assembly of Monolayer-Protected Gold Clusters by Dissolved DNA. Nano Lett. 2004, 4, 95.
   
   
8. Zhang, J.; Wang, G.; Shon,Y.-S.; Zhou, O.; Superfine, R. and Murray, R. W. Interactions of Small Molecules and Au Nanoparticles with Solubilized Single-Wall Carbon Nanotubes. J. Phys. Chem. B 2003, 107, 3726.
   
   
9. Wang, G.; Zhang, J. and Murray, R. W. DNA binding of an ethidium intercalator attached to a monolayer-protected gold cluster. Anal. Chem. (accelerated article) 2002, 74, 4320.
   
   

Patent:
H. S. White; B. Zhang; R. J. White; E. N. Ervin; G. Wang. “Nanopore Electrode, Nanopore Membranes, Methods of Preparation and Surface Modification and Use Thereof” patent filed

Book Chapter:
Bo Zhang, Gangli Wang, and Henry S. White, “Glass nanopore electrodes” in Handbook of Electrochemistry, Cynthia G. Zoski, Ed., Elsevier, in press 2006