Research in the Henary Laboratory at Georgia State University in Atlanta, Georgia focuses on synthetic organic chemistry. Our group is interested in the design, synthesis and development of pharmaceutical agents, other chemical entities suitable for therapeutic use, and imaging technology, such as cancer imaging dyes, invisible markers, and fluorescent probes. We aim to establish several collaborations with analytical chemists, biologists, biochemists, and physicians to facilitate the design and developmental process of small molecules with significant biological activity.
Recent News and Updates
2013
Congratulations to Andy Levitz for successfully defending his MS Thesis and graduating! Excellent work!
Phong Nguyen placed 1st place for his poster presentation and Tyler Dost placed 3rd for his oral presentation at the LSAMP conference! Well done!
The paper detailing targeted NIR imaging was been published in Nature Biotechnology.
Choi, H. S., Gibbs, S. L., Lee, J., H., Kim, S. H., Ashitate, Y., Liu, F., Hyun, H., Park G. L., Xie, Y., Bae, S., Henary, M., Frangioni, J. V. “Targeted Zwitterionic Near-Infrared Fluorophores for Improved Optical Imaging”. Nat Biotechnol 2013, In Press
Two invited research articles were published in the journal Biomedical Materials!
Owens, E.A., Hyun, H., Kim, S. H., Lee, J. H., Park, G., Ashitate, Y., Choi, J., Hong, G. H., Alyabyev, S., Lee, S. J., Khang, G., Henary, M.*, Choi, H. S.* “Highly charged cyanine fluorophores for trafficking scaffold degradation”. Biomedical Materials. 2013, In Press
Kim, S. H., Park, G., Lee, J. H., Ashitate, Y., Choi, J., Hong, G. H., Owens, E.A., Henary, M.,*Choi, H.S.* “Near-infrared lipophilic fluorophores for tracing tissue growth”. Biomedical Materials. 2013; in press
Congratulations to Shirish Paranjpe for successfully defending his MS Thesis and graduating! Excellent work!
Great job Eddie, Rita and Eric for finalizing their exciting paper on the synthesis and red-shifted optical properties of novel monomethine cyanines.
Soriano, E., Outler, L., Owens, E.A., Henary, M.* Synthesis of Asymmetric Monomethine Cyanine Dyes with Red Shifted Optical Properties. J. Heterocycl. Chem. 2013; in press.
2012
The paper Halogenated Pentamethine Cyanine Dyes Exhibiting High Fidelity for G-Quadruplex DNA has been published in Bioorganic and Medicinal Chemistry in collaboration with Dr. Wilson at GSU. Wunderbar!
Nanjunda, R., Owens, E. A., Mickelson, L., Alyabyev, S., Kilpatrick, N., Wang, S., Henary, M., Wilson, D. W., Halogenated Pentamethine Cyanine Dyes Exhibiting High Fidelity for G-Quadruplex DNA. Bioorg. & Med. Chem. 2012 20 (24) 6895-7222.
The paper Development of Carbocyanine Dyes for PRMT Inhibition and Imaging has been published in the European Journal of Medicinal Chemistry in collaboration with Dr. Zheng at GSU. Excellent work!
Sarmistha, S.H., Owens, E. A., Feng, Y., Yang, Y., Xie, Y., Tu, Y., Henary, M., Zheng, Y. G., Development of Carbocyanine Dyes for PRMT Inhibition and Imaging. EJMC. 2012 54:647-59
Eric Owens has successfully defended his Masters Thesis entitled “Synthetic Development of the Tri- and Pentamethine Cyanine Chromophore for Biomolecular Interactions”
Dr. Henary’s internal Faculty Mentor Grant proposal was recommended for funding with Dr. David Wilson.
The Manuscript entitled “The solvatochromic effects of side chain substitution on the binding interaction of novel tricarbocyanine dyes with human serum albumin” was accepted in Talanta. This work was completed in collaboration with Dr. Gabor Patonay and Garfield Beckford.
Beckford, G., Owens, E., Henary, M., Patonay, G. "The solvatochromic effects of side chain substitution on the binding interaction of novel tricarbocyanine dyes with human serum albumin" 2012 Talanta Journal. In Press
Dr. Henary’s grant proposal to the Georgia Cancer Coalition was recommended for funding.
The Manuscript entitled “Near infrared active heptacyanine dyes with unique cancer-imaging and cytotoxic properties” was recently published Bioorganic and Medicinal Chemistry Letters in collaboration with Dr. Rtiu Aneja and Vashali Pannu in the Biology Department at GSU.
Henary, M., Pannu, V., Owens, E. A., Aneja, R. "Near infrared active heptacyanine dyes with unique cancer-imaging and cytotoxic properties" Bioorg. & Med. Chem. Let. 2012, 22 (2) 1242-1246.
