http://www.gsu.edu
Research in the Henary Laboratory at Georgia State University in Downtown Atlanta, Georgia focuses on synthetic organic chemistry.  Our group is interested in the design, synthesis and development of pharmaceutical agents, other chemical entities suitable for therapeutic use and imaging technology, such as cancer imaging dyes, invisible markers, and fluorescent probes. We aim to establish several collaborations with analytical chemists, biologists, biochemists, and physicians to facilitate the design and developmental process of small molecules with significant biological activity.

2014


Yogesh’s paper detailing the synthetic methods, an interesting silica-gel catalyzed acyl rearrangement and biological efficacy of a series of hydroxychavicol analogs has been accepted for publication in the European Journal of Medicinal Chemistry in collaboration with Dr. Ritu Aneja in the Biology Department at GSU.  Great work Yogesh!


Yadav, Y., Owens, E.A., Sharma, V., Aneja, R. Synthesis and evaluation of antiproliferative activity of a novel series of hydroxychavicol analogs. EJMC 2014 75 1-10.











2013


Exciting photocleavage results using cyanine compounds and irradiation with red-shifted light have recently been published in Bioorganic and Medicinal Chemistry Letters in collaboration with Dr. Kathryn Grant at GSU.  Great work- the graphical abstract from this paper is shown below.


Carla T. Mapp, Eric A. Owens, Maged Henary, Kathryn B. Grant. Oxidative cleavage of DNA by pentamethine carbocyanine dyes irradiated with long-wavelength visible light. Bioorganic & Medicinal Chemistry Letters, Available online 25 November 2013.




Andy, Eric and Vince recently presented their work at the SERMACS 2013 conference in Atlanta, GA.  Andy and Eric were in the Medicinal Chemistry Poster Session and Vince presented in the Organic Division.  Dr. Henary also gave a great Oral Presentation in the Medicinal Chemistry section based on exciting results from our lab.


Our paper detailing the trimethine cyanines interactions with G-quadruplex DNA has been published in a special issue of Molecules focused on the quadruplex.  This paper was in collaboration with Drs. Germann and Wilson at GSU. Exciting news!  The graphical abstract is shown below.


Rupesh Nanjunda, Eric A. Owens, Leah Mickelson, Tyler L. Dost, Ekaterina M. Stroeva, Hang T. Huynh, Markus W. Germann, Maged M. Henary, W. David Wilson, Selective G-Quadruplex DNA Recognition by a New Class of Designed Cyanines Molecules 2013, 18(11), 13588-13607.



Andy recently published his review article on the synthesis and applications of unsymmetrical cyanines in Dyes and Pigments! Congratulations!


A. Levitz, M. Henary, Synthesis and applications of unsymmetrical carbocyanine dyes, Dyes and Pigments, 2013, 99, 3, 1107-1116.


Congratulations to Andy Levitz for successfully defending his MS Thesis and graduating! Excellent work!


Phong Nguyen placed 1st place for his poster presentation and Tyler Dost placed 3rd for his oral presentation at the LSAMP conference!  Well done!


The paper detailing targeted NIR imaging was been published in Nature Biotechnology.


Choi, H. S., Gibbs, S. L., Lee, J., H., Kim, S. H., Ashitate, Y., Liu, F., Hyun, H., Park G. L., Xie, Y., Bae, S., Henary, M., Frangioni, J. V. “Targeted Zwitterionic Near-Infrared Fluorophores for Improved Optical Imaging”. Nat Biotechnol 2013, In Press


Two invited research articles were published in the journal Biomedical Materials!


Owens, E.A., Hyun, H., Kim, S. H., Lee, J. H., Park, G., Ashitate, Y., Choi, J., Hong, G. H., Alyabyev, S., Lee, S. J., Khang, G., Henary, M.*, Choi, H. S.* “Highly charged cyanine fluorophores for trafficking scaffold degradation”. Biomedical Materials. 2013, In Press


Kim, S. H., Park, G., Lee, J. H., Ashitate, Y., Choi, J., Hong, G. H., Owens, E.A., Henary, M.,*Choi, H.S.* “Near-infrared lipophilic fluorophores for tracing tissue growth”. Biomedical Materials. 2013; in press


Congratulations to Shirish Paranjpe for successfully defending his MS Thesis and graduating! Excellent work!


Great job Eddie, Rita and Eric for finalizing their exciting paper on the synthesis and red-shifted optical properties of novel monomethine cyanines.


Soriano, E., Outler, L., Owens, E.A., Henary, M.* Synthesis of Asymmetric Monomethine Cyanine Dyes with Red Shifted Optical Properties. J. Heterocycl. Chem. 2013; in press.


2012


The paper Halogenated Pentamethine Cyanine Dyes Exhibiting High Fidelity for G-Quadruplex DNA has been published in Bioorganic and Medicinal Chemistry in collaboration with Dr. Wilson at GSU. Wunderbar!


Nanjunda, R., Owens, E. A., Mickelson, L., Alyabyev, S., Kilpatrick, N., Wang, S., Henary, M., Wilson, D. W., Halogenated Pentamethine Cyanine Dyes Exhibiting High Fidelity for G-Quadruplex DNA. Bioorg. & Med. Chem. 2012 20 (24) 6895-7222.












The paper Development of Carbocyanine Dyes for PRMT Inhibition and Imaging has been published in the European Journal of Medicinal Chemistry in collaboration with Dr. Zheng at GSU.  Excellent work!


Sarmistha, S.H., Owens, E. A., Feng, Y., Yang, Y., Xie, Y., Tu, Y., Henary, M., Zheng, Y. G., Development of Carbocyanine Dyes for PRMT Inhibition and Imaging. EJMC. 2012 54:647-59










Eric Owens has successfully defended his Masters Thesis entitled “Synthetic Development of the Tri- and Pentamethine Cyanine Chromophore for Biomolecular Interactions”


Dr. Henary’s internal Faculty Mentor Grant proposal was recommended for funding with Dr. David Wilson.


The Manuscript entitled “The solvatochromic effects of side chain substitution on the binding interaction of novel tricarbocyanine dyes with human serum albumin” was accepted in Talanta.  This work was completed in collaboration with Dr. Gabor Patonay and Garfield Beckford.


Beckford, G., Owens, E., Henary, M., Patonay, G. "The solvatochromic effects of side chain     substitution on the binding interaction of novel tricarbocyanine dyes with human serum albumin"      2012 Talanta Journal. In Press


Dr. Henary’s grant proposal to the Georgia Cancer Coalition was recommended for funding.


The Manuscript entitled “Near infrared active heptacyanine dyes with unique cancer-imaging and cytotoxic properties” was recently published Bioorganic and Medicinal Chemistry Letters in collaboration with Dr. Ritu Aneja and Vashali Pannu in the Biology Department at GSU.


Henary, M., Pannu, V., Owens, E. A., Aneja, R. "Near infrared active heptacyanine dyes with             unique cancer-imaging and cytotoxic properties" Bioorg. & Med. Chem. Let. 2012, 22 (2) 1242-1246.



 

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